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Tbio
A1BG
Alpha-1B-glycoprotein

Protein Summary
Description
The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263100
  • ENSP00000263100
  • ENSG00000121410

Symbol
  • A1B
  • ABG
  • GAB
  • HYST2477
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.65
protein domain
0.58
tissue
0.53
tissue sample
0.52
cellular component
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.52   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.52   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999950657
p_ni:  2.55e-7
p_wrong:  0.000049088
Score:  0.219
Data Source:  BioPlex,STRINGDB
ZBTB40
Tbio
Family:  TF
Novelty:  0.17413605
p_int:  0.99977983
p_ni:  0.000215721
p_wrong:  0.000004449
Score:  0.209
Data Source:  BioPlex,STRINGDB
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.99485253
p_ni:  0.005147469
Score:  0.163
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.994642469
p_ni:  0.00535753
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
WDR62
Tbio
Novelty:  0.02611137
p_int:  0.98555863
p_ni:  0.01444137
Score:  0.189
Data Source:  BioPlex,STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.980462808
p_ni:  0.019536927
p_wrong:  2.66e-7
Score:  0.532
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.977000212
p_ni:  0.022999788
Score:  0.305
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.948668092
p_ni:  0.051331908
Score:  0.159
Data Source:  BioPlex,STRINGDB
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.928494367
p_ni:  0.071505633
Score:  0.179
Data Source:  BioPlex,STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.889234954
p_ni:  0.110763111
p_wrong:  0.000001935
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Platelet activation, signaling and aggregation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
89.1
platelet crit
1
1
1
58.4
platelet count
1
1
1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.1
platelet crit
1
58.4
platelet count
1
32.7
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-1-B glycoprotein
742390
Macaque
alpha-1-B glycoprotein
712737
Mouse
MGI:2152878
117586
Rat
RGD:69417
140656
Dog
alpha-1-B glycoprotein
VGNC:37398
484230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-1-B glycoprotein
Macaque
alpha-1-B glycoprotein
Mouse
Rat
Dog
alpha-1-B glycoprotein
Publication Statistics
PubMed Score 195.52
PubMed score by year
PubTator Score 384.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title