Tbio THY1 Thy-1 membrane glycoprotein

Protein Summary

Description

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P04216
• Q16008
• Q9NSP1

Gene Name

• THY1

Ensembl ID

• ENST00000284240
• ENSP00000284240
• ENSG00000154096
• ENST00000528522
• ENSP00000431301

Symbol

• CD90
• CDw90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
cellular component	0.95
PubMedID	0.93
gene perturbation	0.91
molecular function	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.6   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 1867   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.6   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 1867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (330)

Explore Interacting Targets

1 – 10 of 330

• See Interactions on String-DB

GPAA1

Tbio

Novelty:  0.01874575

p_int:  0.999893691

p_ni:  0.00010631

Data Source:  BioPlex

PIGU

Tbio

Novelty:  0.11800036

p_int:  0.994592335

p_ni:  0.005407665

Data Source:  BioPlex

MFN2

Tbio

Novelty:  0.00137876

p_int:  0.991002024

p_ni:  0.008620313

p_wrong:  0.000377663

Data Source:  BioPlex

PIGS

Tdark

Family:  Enzyme

Novelty:  0.36443235

p_int:  0.984350121

p_ni:  0.015649879

Data Source:  BioPlex

STEAP3

Tbio

Family:  Enzyme

Novelty:  0.02042104

p_int:  0.966758975

p_ni:  0.018555364

p_wrong:  0.014685661

Data Source:  BioPlex

GHITM

Tbio

Novelty:  0.00360652

p_int:  0.953969505

p_ni:  0.046030485

p_wrong:  9e-9

Data Source:  BioPlex

PIGT

Tbio

Family:  Enzyme

Novelty:  0.02539879

p_int:  0.947476052

p_ni:  0.052523948

Score:  0.167

Data Source:  BioPlex,STRINGDB

ZNF593

Tbio

Novelty:  0.45276787

p_int:  0.901786419

p_ni:  0.098175181

p_wrong:  0.0000384

Data Source:  BioPlex

PIGK

Tbio

Family:  Enzyme

Novelty:  0.02333499

p_int:  0.886487015

p_ni:  0.113512985

Data Source:  BioPlex

LRRC8A

Tbio

Novelty:  0.0163093

p_int:  0.752400137

p_ni:  0.247599534

p_wrong:  3.29e-7

Data Source:  BioPlex

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Downstream (2)

1 – 2 of 2

ROCK2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  1

1: Leukocyte transendothelial migration

ROCK1

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  1

1: Leukocyte transendothelial migration

Pathways (31)

Reactome (3)

KEGG (1)

PathwayCommons (4)

WikiPathways (23)

Metabolism of proteins (R-HSA-392499)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (46)

Functions (4)

Components (18)

Processes (24)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
integrin binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
protein kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GPI anchor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
GTPase activator activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	4	3	4		86.3
platelet count	EFO_0004309	1	1	1		76.8
longevity	EFO_0004300	1	1	0	7.6	66.8
refractive error measurement	EFO_0007814	1	3	3		60.9
glomerular filtration rate	EFO_0005208	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	4		86.3
platelet count	EFO_0004309	1		76.8
longevity	EFO_0004300	0	7.6	66.8
refractive error measurement	EFO_0007814	3		60.9
glomerular filtration rate	EFO_0005208	1		49.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
GPI-anchor
Immunoglobulin domain
Lipoprotein
Membrane
Phosphoprotein
Pyrrolidone carboxylic acid

GWAS Trait Find Similar Targets

No Header	No Header
glomerular filtration rate
high density lipoprotein cholesterol measurement
intraocular pressure measurement
longevity
parental longevity
platelet count
refractive error measurement
urate measurement
uric acid measurement

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Thy-1 cell surface antigen	VGNC:8275	451611
Macaque	Thy-1 cell surface antigen		705321
Mouse	thymus cell antigen 1, theta	MGI:98747	21838
Rat	Thy-1 cell surface antigen	RGD:3860	24832
Dog	Thy-1 cell surface antigen	VGNC:47362	489365

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Thy-1 cell surface antigen
Macaque	Thy-1 cell surface antigen
Mouse	thymus cell antigen 1, theta
Rat	Thy-1 cell surface antigen
Dog	Thy-1 cell surface antigen

Publication Statistics

PubMed Score 2801.60

PubMed score by year

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PubTator Score 1201.31

PubTator score by year

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Related Publications

Text Mined References (185)

GeneRif Annotations (77)

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10

0 of 0

PMID	Year	Title