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Tbio
THY1
Thy-1 membrane glycoprotein

Protein Summary
Description
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284240
  • ENSP00000284240
  • ENSG00000154096
  • ENST00000528522
  • ENSP00000431301

Symbol
  • CD90
  • CDw90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
cellular component
0.95
PubMedID
0.93
gene perturbation
0.91
molecular function
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.6   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 1867   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.6   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 1867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (330)
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.999893691
p_ni:  0.00010631
Data Source:  BioPlex
PIGU
Tbio
Novelty:  0.11800036
p_int:  0.994592335
p_ni:  0.005407665
Data Source:  BioPlex
MFN2
Tbio
Novelty:  0.00137876
p_int:  0.991002024
p_ni:  0.008620313
p_wrong:  0.000377663
Data Source:  BioPlex
PIGS
Tdark
Family:  Enzyme
Novelty:  0.36443235
p_int:  0.984350121
p_ni:  0.015649879
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.966758975
p_ni:  0.018555364
p_wrong:  0.014685661
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.953969505
p_ni:  0.046030485
p_wrong:  9e-9
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.947476052
p_ni:  0.052523948
Score:  0.167
Data Source:  BioPlex,STRINGDB
ZNF593
Tbio
Novelty:  0.45276787
p_int:  0.901786419
p_ni:  0.098175181
p_wrong:  0.0000384
Data Source:  BioPlex
PIGK
Tbio
Family:  Enzyme
Novelty:  0.02333499
p_int:  0.886487015
p_ni:  0.113512985
Data Source:  BioPlex
LRRC8A
Tbio
Novelty:  0.0163093
p_int:  0.752400137
p_ni:  0.247599534
p_wrong:  3.29e-7
Data Source:  BioPlex
Pathways (31)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
3
4
86.3
platelet count
1
1
1
76.8
longevity
1
1
0
7.6
66.8
refractive error measurement
1
3
3
60.9
glomerular filtration rate
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
86.3
platelet count
1
76.8
longevity
0
7.6
66.8
refractive error measurement
3
60.9
glomerular filtration rate
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Thy-1 cell surface antigen
VGNC:8275
451611
Macaque
Thy-1 cell surface antigen
705321
Mouse
MGI:98747
21838
Rat
RGD:3860
24832
Dog
Thy-1 cell surface antigen
VGNC:47362
489365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Thy-1 cell surface antigen
Macaque
Thy-1 cell surface antigen
Mouse
Rat
Dog
Thy-1 cell surface antigen
Publication Statistics
PubMed Score 2801.60
PubMed score by year
PubTator Score 1201.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title