You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
THY1
Thy-1 membrane glycoprotein

Protein Summary
Description
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284240
  • ENSP00000284240
  • ENSG00000154096
  • ENST00000528522
  • ENSP00000431301

Symbol
  • CD90
  • CDw90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
cellular component
0.95
PubMedID
0.93
gene perturbation
0.91
molecular function
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2763.05   (req: < 5)
View Publications
Gene RIFs: 77   (req: <= 3)
View Gene RIFs
Antibodies: 1867   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2763.05   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 1867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Thy-1 cell surface antigen
VGNC:8275
451611
Macaque
Thy-1 cell surface antigen
705321
Mouse
thymus cell antigen 1, theta
MGI:98747
21838
Rat
Thy-1 cell surface antigen
RGD:3860
24832
Dog
Thy-1 cell surface antigen
VGNC:47362
489365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Thy-1 cell surface antigen
Macaque
Thy-1 cell surface antigen
Mouse
thymus cell antigen 1, theta
Rat
Thy-1 cell surface antigen
Dog
Thy-1 cell surface antigen
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P04216-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (31)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
2050 targets
R-HSA-392499
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
94 targets
R-HSA-163125
Reactome
Post-translational protein modification
1450 targets
R-HSA-597592
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
2050 targets
R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins
94 targets
R-HSA-163125
Post-translational protein modification
1450 targets
R-HSA-597592
Gene Ontology Terms (46)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
integrin binding
Inferred from Mutant Phenotype (IMP)
UniProtKB
protein kinase binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GPI anchor binding
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GTPase activator activity
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (330)
1 – 10 of 330
GPAA1
Tbio
Novelty: 0.01874575
p_int: 0.999893691
p_ni: 0.00010631
Data Source: BioPlex
PIGU
Tbio
Novelty: 0.11800036
p_int: 0.994592335
p_ni: 0.005407665
Data Source: BioPlex
MFN2
Tbio
Novelty: 0.00137876
p_int: 0.991002024
p_ni: 0.008620313
p_wrong: 0.000377663
Data Source: BioPlex
PIGS
Tdark
Family: Enzyme
Novelty: 0.36443235
p_int: 0.984350121
p_ni: 0.015649879
Data Source: BioPlex
STEAP3
Tbio
Family: Enzyme
Novelty: 0.02042104
p_int: 0.966758975
p_ni: 0.018555364
p_wrong: 0.014685661
Data Source: BioPlex
GHITM
Tbio
Novelty: 0.00360652
p_int: 0.953969505
p_ni: 0.046030485
p_wrong: 9e-9
Data Source: BioPlex
PIGT
Tbio
Family: Enzyme
Novelty: 0.02539879
p_int: 0.947476052
p_ni: 0.052523948
Score: 0.167
Data Source: BioPlex,STRINGDB
ZNF593
Tbio
Novelty: 0.45276787
p_int: 0.901786419
p_ni: 0.098175181
p_wrong: 0.0000384
Data Source: BioPlex
PIGK
Tbio
Family: Enzyme
Novelty: 0.02333499
p_int: 0.886487015
p_ni: 0.113512985
Data Source: BioPlex
LRRC8A
Tbio
Novelty: 0.0163093
p_int: 0.752400137
p_ni: 0.247599534
p_wrong: 3.29e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  2763.05

PubMed score by year
PubTator Score  1201.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer