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Tchem
MAS1
Proto-oncogene Mas

Protein Summary
Description
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252660
  • ENSP00000252660
  • ENSG00000130368

Symbol
  • MAS
  • MAS
  • MGRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
gene perturbation
0.84
protein domain
0.58
tissue
0.57
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.46   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.46   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
AVE 0991
chemical structure image
AR244555
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
1
1
0
12.4
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
0
12.4
21.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAS1 proto-oncogene, G protein-coupled receptor
VGNC:11114
472176
Macaque
proto-oncogene Mas
703105
Mouse
MGI:96918
17171
Rat
RGD:3049
25153
Cow
MAS1 proto-oncogene, G protein-coupled receptor
VGNC:31254
783010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAS1 proto-oncogene, G protein-coupled receptor
Macaque
proto-oncogene Mas
Mouse
Rat
Cow
MAS1 proto-oncogene, G protein-coupled receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P04201-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (91)
1 – 10 of 91
GPR50
Tbio
Family: GPCR
Novelty: 0.0110136
p_int: 0.999853803
p_ni: 0.000146188
p_wrong: 9e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.999658732
p_ni: 0.000341259
p_wrong: 9e-9
Data Source: BioPlex
EFHD1
Tbio
Novelty: 0.00808906
p_int: 0.999423918
p_ni: 0.000280672
p_wrong: 0.000295411
Score: 0.151
Data Source: BioPlex,STRINGDB
ABCD1
Tbio
Family: Transporter
Novelty: 0.0067013
p_int: 0.999055897
p_ni: 0.000944103
p_wrong: 1e-9
Data Source: BioPlex
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
p_int: 0.99817486
p_ni: 0.00182514
Data Source: BioPlex
RELT
Tbio
Novelty: 0.07977949
p_int: 0.996772285
p_ni: 0.003227183
p_wrong: 5.32e-7
Data Source: BioPlex
SELENBP1
Tbio
Novelty: 0.00758018
p_int: 0.99550459
p_ni: 0.004495409
p_wrong: 1e-9
Data Source: BioPlex
SLC35G2
Tdark
Family: Transporter
Novelty: 0.57896683
p_int: 0.9945707
p_ni: 0.000788149
p_wrong: 0.004641151
Data Source: BioPlex
PKP3
Tbio
Novelty: 0.0269462
p_int: 0.993381404
p_ni: 0.006613782
p_wrong: 0.000004813
Data Source: BioPlex
ZYX
Tbio
Novelty: 0.00375452
p_int: 0.993198042
p_ni: 0.006801948
p_wrong: 1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  109.46

PubMed score by year
PubTator Score  49.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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