MYCN
N-myc proto-oncogene protein
Protein Summary
Positively regulates the transcription of MYCNOS in neuroblastoma cells. This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
- ENST00000281043
- ENSP00000281043
- ENSG00000134323
- BHLHE37
- NMYC
- NMYC
- ODED
- MODED
- N-myc
- bHLHe37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
cell type or tissue | 0.81 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.77 | ||
microRNA | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2940.07 (req: < 5)
Gene RIFs: 431 (req: <= 3)
Antibodies: 321 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2940.07 (req: >= 5)
Gene RIFs: 431 (req: > 3)
Antibodies: 321 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0