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Tchem
TK1
Thymidine kinase, cytosolic

Protein Summary
Description
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301634
  • ENSP00000301634
  • ENSG00000167900

Symbol
  • TK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor perturbation
0.96
transcription factor binding site profile
0.82
interacting protein
0.81
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 765.32   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 765.32   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
4
84
mean corpuscular volume
1
1
1
56.6
mean reticulocyte volume
1
1
1
53.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
84
mean corpuscular volume
1
56.6
mean reticulocyte volume
1
53.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymidine kinase 1
VGNC:9711
742176
Macaque
thymidine kinase 1
709403
Mouse
MGI:98763
21877
Rat
RGD:621014
24834
Dog
thymidine kinase 1
VGNC:47389
100855947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymidine kinase 1
Macaque
thymidine kinase 1
Mouse
Rat
Dog
thymidine kinase 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04183-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Metabolism
Protein-Protein Interactions (233)
1 – 10 of 233
AGRP
Tbio
Novelty: 0.00147804
p_int: 0.999867076
p_ni: 0.000132924
Score: 0.392
Data Source: BioPlex,STRINGDB
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.999781926
p_ni: 0.000218074
Score: 0.163
Data Source: BioPlex,STRINGDB
CRIP1
Tbio
Novelty: 0.01263063
p_int: 0.997103737
p_ni: 0.002896263
Score: 0.282
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.985916126
p_ni: 0.014083874
Score: 0.493
Data Source: BioPlex,STRINGDB
MAMDC2
Tdark
Novelty: 0.22933145
p_int: 0.961605185
p_ni: 0.038394815
Score: 0.529
Data Source: BioPlex,STRINGDB
EDA2R
Tbio
Novelty: 0.03463669
p_int: 0.930512336
p_ni: 0.069487664
Score: 0.261
Data Source: BioPlex,STRINGDB
ZNF232
Tdark
Family: TF
Novelty: 0.68288358
p_int: 0.897147861
p_ni: 0.102852135
p_wrong: 4e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.807893331
p_ni: 0.192106668
p_wrong: 1e-9
Data Source: BioPlex
PM20D2
Tdark
Family: Enzyme
Novelty: 0.63491472
p_int: 0.802131713
p_ni: 0.197868286
p_wrong: 1e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
ZNF202
Tbio
Family: TF
Novelty: 0.06306212
p_int: 0.784793674
p_ni: 0.215206325
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  765.32

PubMed score by year
PubTator Score  305.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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