TK1
Thymidine kinase, cytosolic
Protein Classes
Protein Summary
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
- ENST00000301634
- ENSP00000301634
- ENSG00000167900
- TK2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
transcription factor perturbation | 0.96 | ||
transcription factor binding site profile | 0.82 | ||
interacting protein | 0.81 | ||
biological process | 0.8 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 765.32 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 397 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 765.32 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 397 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (2)
1 – 2 of 2
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 2 | 4 | 84 | |||||
mean corpuscular volume | 1 | 1 | 1 | 56.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 53.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 84 | |||||
mean corpuscular volume | 1 | 56.6 | |||||
mean reticulocyte volume | 1 | 53.5 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thymidine kinase 1 | VGNC:9711 | 742176 | |||||
Macaque | thymidine kinase 1 | 709403 | ||||||
Mouse | MGI:98763 | 21877 | ||||||
Rat | RGD:621014 | 24834 | ||||||
Dog | thymidine kinase 1 | VGNC:47389 | 100855947 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thymidine kinase 1 | |||||
Macaque | thymidine kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | thymidine kinase 1 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (19)
Reactome (9)
KEGG (3)
PathwayCommons (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | G1/S Transition | ||||
Reactome | G1/S-Specific Transcription | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
G1/S Transition | ||||
G1/S-Specific Transcription | ||||
Metabolism | ||||
Gene Ontology Terms (12)
Functions (5)
Components (1)
Processes (6)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (233)
1 – 10 of 233
AGRP
Novelty: 0.00147804
p_int: 0.999867076
p_ni: 0.000132924
Score: 0.392
Data Source: BioPlex,STRINGDB
NCS1
Novelty: 0.0051468
p_int: 0.999781926
p_ni: 0.000218074
Score: 0.163
Data Source: BioPlex,STRINGDB
CRIP1
Novelty: 0.01263063
p_int: 0.997103737
p_ni: 0.002896263
Score: 0.282
Data Source: BioPlex,STRINGDB
FZR1
Novelty: 0.01599606
p_int: 0.985916126
p_ni: 0.014083874
Score: 0.493
Data Source: BioPlex,STRINGDB
MAMDC2
Novelty: 0.22933145
p_int: 0.961605185
p_ni: 0.038394815
Score: 0.529
Data Source: BioPlex,STRINGDB
EDA2R
Novelty: 0.03463669
p_int: 0.930512336
p_ni: 0.069487664
Score: 0.261
Data Source: BioPlex,STRINGDB
ZNF232
Family: TF
Novelty: 0.68288358
p_int: 0.897147861
p_ni: 0.102852135
p_wrong: 4e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
PLA2G10
Family: Enzyme
Novelty: 0.00289317
p_int: 0.807893331
p_ni: 0.192106668
p_wrong: 1e-9
Data Source: BioPlex
PM20D2
Family: Enzyme
Novelty: 0.63491472
p_int: 0.802131713
p_ni: 0.197868286
p_wrong: 1e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
ZNF202
Family: TF
Novelty: 0.06306212
p_int: 0.784793674
p_ni: 0.215206325
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 765.32
PubMed score by year
PubTator Score 305.79
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
MGI Phenotype