OAT
Ornithine aminotransferase, mitochondrial
Protein Summary
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
- ENST00000368845
- ENSP00000357838
- ENSG00000065154
- ENST00000539214
- ENSP00000439042
- OKT
- GACR
- HOGA
- OATASE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
interacting protein | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor binding site profile | 0.83 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 802.73 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 802.73 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0