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Tchem
OAT
Ornithine aminotransferase, mitochondrial

Protein Summary
Description
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368845
  • ENSP00000357838
  • ENSG00000065154
  • ENST00000539214
  • ENSP00000439042

Symbol
  • OKT
  • GACR
  • HOGA
  • OATASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
interacting protein
0.92
kinase perturbation
0.91
transcription factor binding site profile
0.83
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.25   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.25   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (147)
1 – 10 of 147
ALDH18A1
Tbio
Family: Enzyme
Novelty: 0.00301673
Score: 0.997
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.991
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.988
Data Source: STRINGDB
ODC1
Tclin
Family: Enzyme
Novelty: 0.00037968
Score: 0.987
Data Source: STRINGDB
ALDH4A1
Tbio
Family: Enzyme
Novelty: 0.01316227
Score: 0.983
Data Source: STRINGDB
OTC
Tchem
Family: Enzyme
Novelty: 0.00544004
Score: 0.956
Data Source: STRINGDB
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
Score: 0.932
Data Source: STRINGDB
NAGS
Tbio
Family: Enzyme
Novelty: 0.0051524
Score: 0.903
Data Source: STRINGDB
ASL
Tbio
Family: Enzyme
Novelty: 0.00624709
Score: 0.887
Data Source: STRINGDB
PRODH
Tbio
Family: Enzyme
Novelty: 0.00315806
Score: 0.85
Data Source: STRINGDB
Publication Statistics
PubMed Score  756.25

PubMed score by year
PubTator Score  154.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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