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Tbio
SOD2
Superoxide dismutase [Mn], mitochondrial

Protein Summary
Description
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337404
  • ENSP00000337127
  • ENSG00000112096
  • ENST00000367054
  • ENSP00000356021
  • ENST00000367055
  • ENSP00000356022
  • ENST00000444946
  • ENSP00000404804
  • ENST00000538183
  • ENSP00000446252

Symbol
  • IPOB
  • IPO-B
  • MNSOD
  • MVCD6
  • Mn-SOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
transcription factor perturbation
1
virus perturbation
0.98
transcription factor binding site profile
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.05   (req: < 5)
Gene RIFs: 553   (req: <= 3)
Antibodies: 961   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.05   (req: >= 5)
Gene RIFs: 553   (req: > 3)
Antibodies: 961   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (494)
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.986386644
p_ni:  0.013613356
Score:  0.537
Data Source:  BioPlex,STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.998
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.998
Data Source:  STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.995
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.994
Data Source:  STRINGDB
GPX1
Tbio
Family:  Enzyme
Novelty:  0.000826
Score:  0.988
Data Source:  STRINGDB
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
Score:  0.987
Data Source:  Reactome,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
Score:  0.977
Data Source:  STRINGDB
GPX3
Tbio
Family:  Enzyme
Novelty:  0.0015734
Score:  0.974
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.973
Data Source:  STRINGDB
Pathways (34)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
42.6
low density lipoprotein cholesterol measurement
2
1
2
30.9
cholesteryl esters:total lipids ratio
1
1
1
30.9
phospholipids:total lipids ratio
1
1
1
18
very low density lipoprotein cholesterol measurement
4
1
4
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
42.6
low density lipoprotein cholesterol measurement
2
30.9
cholesteryl esters:total lipids ratio
1
30.9
phospholipids:total lipids ratio
1
18
very low density lipoprotein cholesterol measurement
4
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 2
VGNC:52105
449634
Macaque
superoxide dismutase 2
574097
Mouse
MGI:98352
20656
Rat
RGD:3732
24787
Dog
superoxide dismutase 2
VGNC:53988
476258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 2
Macaque
superoxide dismutase 2
Mouse
Rat
Dog
superoxide dismutase 2
Publication Statistics
PubMed Score 1346.05
PubMed score by year
PubTator Score 2082.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title