Tbio SOD2 Superoxide dismutase [Mn], mitochondrial

Protein Summary

Description

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• P04179
• B2R7R1
• B3KUK2
• B4DL20
• B4E3K9
• E1P5A9
• P78434
• Q16792
• Q5TCM1
• Q96EE6
• Q9P2Z3

Gene Name

• SOD2

Ensembl ID

• ENST00000337404
• ENSP00000337127
• ENSG00000112096
• ENST00000367054
• ENSP00000356021
• ENST00000367055
• ENSP00000356022
• ENST00000444946
• ENSP00000404804
• ENST00000538183
• ENSP00000446252

Symbol

• IPOB
• IPO-B
• MNSOD
• MVCD6
• Mn-SOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
transcription factor perturbation	1
virus perturbation	0.98
transcription factor binding site profile	0.89

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Superoxide Dismutase [Mn], Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Superoxide Dismutase [Mn], Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.05   (req: < 5)

Gene RIFs: 649   (req: <= 3)

Antibodies: 961   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.05   (req: >= 5)

Gene RIFs: 649   (req: > 3)

Antibodies: 961   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0