Protein Summary
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
- ENST00000291527
- ENSP00000291527
- ENSG00000160182
- BCEI
- PS2
- pS2
- BCEI
- HPS2
- HP1.A
- pNR-2
- D21S21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.95 | ||
biological term | 0.81 | ||
chemical | 0.66 | ||
gene perturbation | 0.66 | ||
small molecule perturbation | 0.59 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 358.58 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 838 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 358.58 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 838 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (80)
1 – 10 of 80
ESR1
Family: NR
Novelty: 0.00005938
Score: 0.987
Data Source: STRINGDB
FOXA1
Family: TF
Novelty: 0.00235269
Score: 0.97
Data Source: STRINGDB
GATA3
Family: TF
Novelty: 0.00071141
Score: 0.97
Data Source: STRINGDB
NCOA3
Family: Epigenetic
Novelty: 0.00193529
Score: 0.963
Data Source: STRINGDB
ERBB2
Family: Kinase
Novelty: 0.00003761
Score: 0.948
Data Source: STRINGDB
TFF3
Novelty: 0.00127103
Score: 0.944
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.939
Data Source: STRINGDB
EGFR
Family: Kinase
Novelty: 0.00007274
Score: 0.939
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00055009
Score: 0.931
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.922
Data Source: STRINGDB
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Nuclear Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Signal Transduction | ||||
Signaling by Nuclear Receptors | ||||
Gene Ontology Terms (10)
Functions (1)
Components (2)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.3 | 89.7 | |||||
2 | 2 | 0 | 1.2 | 76.7 | |||||
1 | 2 | 0 | 1.2 | 66.6 | |||||
eosinophil count | 2 | 1 | 2 | 64.9 | |||||
lymphocyte count | 2 | 1 | 2 | 54.4 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 89.7 | |||||
0 | 1.2 | 76.7 | |||||
0 | 1.2 | 66.6 | |||||
eosinophil count | 2 | 64.9 | |||||
lymphocyte count | 2 | 54.4 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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MGI Phenotype
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Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | trefoil factor 1 | VGNC:1121 | 100613424 | |||||
Mouse | MGI:88135 | 21784 | ||||||
Rat | RGD:620707 | 117270 | ||||||
Dog | trefoil factor 1 | VGNC:47296 | 403491 | |||||
Horse | trefoil factor 1 | VGNC:24041 | 100629635 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | trefoil factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | trefoil factor 1 | |||||
Horse | trefoil factor 1 | |||||
Publication Statistics
PubMed Score 358.58
PubMed score by year
PubTator Score 411.32
PubTator score by year