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Tbio
CSF2
Granulocyte-macrophage colony-stimulating factor

Protein Classes
Protein Summary
Description
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296871
  • ENSP00000296871
  • ENSG00000164400

Symbol
  • GMCSF
  • CSF
  • GMCSF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological term
0.99
phenotype
0.96
biological process
0.95
disease
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9596.71   (req: < 5)
Gene RIFs: 196   (req: <= 3)
Antibodies: 1654   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9596.71   (req: >= 5)
Gene RIFs: 196   (req: > 3)
Antibodies: 1654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
2
2
66.4
eosinophil count
2
2
2
65.4
eosinophil percentage of granulocytes
1
1
1
15.9
sum of eosinophil and basophil counts
1
1
1
15.9
neutrophil percentage of granulocytes
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
66.4
eosinophil count
2
65.4
eosinophil percentage of granulocytes
1
15.9
sum of eosinophil and basophil counts
1
15.9
neutrophil percentage of granulocytes
1
15.1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (523)
1 – 10 of 523
CSF2RA
Tclin
Novelty: 0.00125121
Score: 0.996
Data Source: Reactome,STRINGDB
CSF2RB
Tclin
Novelty: 0.02093804
Score: 0.996
Data Source: Reactome,STRINGDB
IL3
Tbio
Novelty: 0.0002336
Score: 0.995
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.994
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.993
Data Source: STRINGDB
IL5
Tclin
Novelty: 0.0001684
Score: 0.989
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.981
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.981
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.979
Data Source: STRINGDB
IL2RA
Tclin
Novelty: 0.0007607
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  9596.71

PubMed score by year
PubTator Score  10208.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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