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Tbio
CLPS
Colipase

Protein Summary
Description
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Enterostatin has a biological activity as a satiety signal. The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259938
  • ENSP00000259938
  • ENSG00000137392
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
kinase perturbation
0.81
gene perturbation
0.76
protein domain
0.58
PubMedID
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.34   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.34   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (13)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary lipid
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary lipid
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (92)
1 – 10 of 92
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.997
Data Source: Reactome,STRINGDB
PNLIPRP1
Tbio
Family: Enzyme
Novelty: 0.04756238
Score: 0.897
Data Source: STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.819
Data Source: STRINGDB
LY6D
Tbio
Novelty: 0.07032941
Score: 0.8
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.799
Data Source: STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.00156761
Score: 0.775
Data Source: STRINGDB
JDP2
Tbio
Family: TF
Novelty: 0.01070757
Score: 0.754
Data Source: STRINGDB
ARL4C
Tbio
Family: Enzyme
Novelty: 0.04764628
Score: 0.747
Data Source: STRINGDB
CPB1
Tchem
Family: Enzyme
Novelty: 0.00108031
Score: 0.725
Data Source: STRINGDB
PNLIPRP3
Tdark
Family: Enzyme
Novelty: 1.16639271
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  407.34

PubMed score by year
PubTator Score  169.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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