Tchem APOB Apolipoprotein B-100

Protein Summary

Description

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04114
• O00502
• P78479
• P78480
• P78481
• Q13779
• Q13785
• Q13786
• Q13787
• Q13788
• Q4ZG63
• Q53QC8
• Q7Z600
• Q9UMN0
• Apo B-100

Gene Name

• APOB

Ensembl ID

• ENST00000233242
• ENSP00000233242
• ENSG00000084674

Symbol

• FLDB
• LDLCQ4
• apoB-48
• apoB-100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
metabolite	1
protein domain	1
biological process	0.98
trait	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13098.78   (req: < 5)

Gene RIFs: 598   (req: <= 3)

Antibodies: 1048   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13098.78   (req: >= 5)

Gene RIFs: 598   (req: > 3)

Antibodies: 1048   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0