Protein Summary
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective ...more
- ENST00000233242
- ENSP00000233242
- ENSG00000084674
- FLDB
- LDLCQ4
- apoB-48
- apoB-100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
metabolite | 1 | ||
protein domain | 1 | ||
biological process | 0.98 | ||
trait | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12323.95 (req: < 5)
Gene RIFs: 506 (req: <= 3)
Antibodies: 1048 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12323.95 (req: >= 5)
Gene RIFs: 506 (req: > 3)
Antibodies: 1048 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 47
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 49
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (49)
Protein-Protein Interactions (578)
RPN2
Family: Enzyme
Novelty: 0.01796569
p_int: 0.984217839
p_ni: 0.015782161
Data Source: BioPlex
YIPF3
Novelty: 0.12021667
p_int: 0.983956843
p_ni: 0.016043005
p_wrong: 1.52e-7
Data Source: BioPlex
ZFYVE27
Novelty: 0.0563358
p_int: 0.959199115
p_ni: 0.040800882
p_wrong: 2e-9
Data Source: BioPlex
ZDHHC11
Family: Enzyme
Novelty: 0.35249931
p_int: 0.956770367
p_ni: 0.043229632
Score: 0.177
Data Source: BioPlex,STRINGDB
SLC37A3
Family: Transporter
Novelty: 0.21571546
p_int: 0.934312432
p_ni: 0.065684641
p_wrong: 0.000002926
Data Source: BioPlex
AUP1
Novelty: 0.0418459
p_int: 0.878641691
p_ni: 0.121358305
p_wrong: 4e-9
Score: 0.545
Data Source: BioPlex,STRINGDB
SSR3
Novelty: 0.05838475
p_int: 0.876032728
p_ni: 0.123095459
p_wrong: 0.000871813
Data Source: BioPlex
RTP2
Novelty: 0.05972678
p_int: 0.875653065
p_ni: 0.123511313
p_wrong: 0.000835622
Data Source: BioPlex
Nearest Tclin Targets
Pathways (53)
Reactome (42)
KEGG (3)
PathwayCommons (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chylomicron assembly | ||||
Reactome | Chylomicron clearance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Cell surface interactions at the vascular wall | ||||
Chylomicron assembly | ||||
Chylomicron clearance | ||||
Viral Interactions (0)
Gene Ontology Terms (72)
Functions (5)
Components (25)
Processes (42)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (37)
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 25 | 41 | 81 | 4.1 | 99.9 | ||||
apolipoprotein B measurement | 2 | 21 | 21 | 99.9 | |||||
total cholesterol measurement | 14 | 37 | 67 | 3.6 | 99.9 | ||||
triglyceride measurement | 16 | 22 | 46 | 6 | 99.8 | ||||
high density lipoprotein cholesterol measurement | 10 | 14 | 31 | 99.6 | |||||
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 81 | 4.1 | 99.9 | ||||
apolipoprotein B measurement | 21 | 99.9 | |||||
total cholesterol measurement | 67 | 3.6 | 99.9 | ||||
triglyceride measurement | 46 | 6 | 99.8 | ||||
high density lipoprotein cholesterol measurement | 31 | 99.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein B | VGNC:171 | 459058 | |||||
Macaque | apolipoprotein B | 702937 | ||||||
Mouse | MGI:88052 | 238055 | ||||||
Rat | RGD:2129 | 54225 | ||||||
Dog | apolipoprotein B | VGNC:37994 | 475680 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | apolipoprotein B | |||||
Macaque | apolipoprotein B | |||||
Mouse | ||||||
Rat | ||||||
Dog | apolipoprotein B | |||||
Publication Statistics
PubMed Score 12323.95
PubMed score by year
PubTator Score 8443.98
PubTator score by year
Related Publications
Text Mined References (753)
GeneRif Annotations (506)
Items per page:
0 of 0
PMID | Year | Title |
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