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Tbio
RLN2
Prorelaxin H2

Protein Summary
Description
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381627
  • ENSP00000371040
  • ENSG00000107014

Symbol
  • H2
  • RLXH2
  • H2-RLX
  • bA12D24.1.1
  • bA12D24.1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
biological term
0.64
protein domain
0.58
tissue
0.57
pathway
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (136)
1 – 10 of 136
RLN1
Tbio
Novelty: 0.05712331
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.845
Data Source: BioPlex,STRINGDB
COL14A1
Tbio
Novelty: 0.00758642
p_int: 0.998894481
p_ni: 0.001105519
Data Source: BioPlex
MCTS1
Tbio
Novelty: 0.1017524
p_int: 0.99828589
p_ni: 0.001714103
p_wrong: 7e-9
Data Source: BioPlex
MIPEP
Tbio
Family: Enzyme
Novelty: 0.02165125
p_int: 0.99740745
p_ni: 0.002592549
p_wrong: 1e-9
Data Source: BioPlex
PCYOX1L
Tdark
Family: Enzyme
Novelty: 3.12186978
p_int: 0.993180308
p_ni: 0.006815291
p_wrong: 0.000004401
Data Source: BioPlex
TENM3
Tbio
Novelty: 0.0087482
p_int: 0.979778328
p_ni: 0.017980665
p_wrong: 0.002241007
Data Source: BioPlex
AIP
Tbio
Novelty: 0.00986784
p_int: 0.898341317
p_ni: 0.101658683
Data Source: BioPlex
RXFP1
Tchem
Family: GPCR
Novelty: 0.00590091
Score: 0.992
Data Source: Reactome,STRINGDB
RXFP2
Tbio
Family: GPCR
Novelty: 0.01111071
Score: 0.98
Data Source: Reactome,STRINGDB
RLN3
Tbio
Novelty: 0.01243441
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  114.51

PubMed score by year
PubTator Score  1643.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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