You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PDGFA
Platelet-derived growth factor subunit A

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354513
  • ENSP00000346508
  • ENSG00000197461
  • ENST00000402802
  • ENSP00000383889

Symbol
  • PDGF1
  • PDGF1
  • PDGF-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
kinase perturbation
0.91
transcription factor perturbation
0.91
small molecule perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.84   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 647.84   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (149)
PDGFRA
Tclin
Family:  Kinase
Novelty:  0.00066909
Score:  0.988
Data Source:  Reactome,STRINGDB
PDGFRB
Tclin
Family:  Kinase
Novelty:  0.00074896
Score:  0.984
Data Source:  Reactome,STRINGDB
PDGFC
Tbio
Novelty:  0.00642236
Score:  0.968
Data Source:  STRINGDB
PDGFD
Tbio
Novelty:  0.00799996
Score:  0.961
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.948
Data Source:  Reactome,STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.947
Data Source:  STRINGDB
PDGFB
Tbio
Novelty:  0.00080876
Score:  0.936
Data Source:  Reactome,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.929
Data Source:  Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.921
Data Source:  Reactome,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (97)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
6
6
94.1
balding measurement
1
3
3
92.8
puberty onset measurement
3
1
3
83
hematocrit
1
1
1
71.2
hemoglobin measurement
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
94.1
balding measurement
3
92.8
puberty onset measurement
3
83
hematocrit
1
71.2
hemoglobin measurement
1
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
platelet derived growth factor subunit A
707725
Mouse
MGI:97527
18590
Rat
RGD:3282
25266
Dog
platelet derived growth factor subunit A
VGNC:44368
491597
Cow
platelet derived growth factor subunit A
VGNC:32689
505908
Species
Name
OMA
EggNOG
Inparanoid
Macaque
platelet derived growth factor subunit A
Mouse
Rat
Dog
platelet derived growth factor subunit A
Cow
platelet derived growth factor subunit A
Publication Statistics
PubMed Score 647.84
PubMed score by year
PubTator Score 366.09
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title