You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANXA1
Annexin A1

Protein Summary
Description
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257497
  • ENSP00000257497
  • ENSG00000135046
  • ENST00000376911
  • ENSP00000366109

Symbol
  • ANX1
  • LPC1
  • ANX1
  • LPC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
1
interacting protein
1
molecular function
1
transcription factor perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1134.02   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 1057   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1134.02   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 1057   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
G alpha (q) signalling events
Gene Ontology Terms (98)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (462)
1 – 10 of 462
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.987850096
p_ni: 0.012149904
Data Source: BioPlex
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.982591822
p_ni: 0.017408178
Score: 0.911
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.978422117
p_ni: 0.021577883
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.882560464
p_ni: 0.11743953
p_wrong: 6e-9
Data Source: BioPlex
KIR2DS2
Tdark
p_int: 0.858904992
p_ni: 0.141095008
Data Source: BioPlex
RPUSD3
Tdark
Family: Enzyme
Novelty: 1.00226099
p_int: 0.856704195
p_ni: 0.143295805
Score: 0.188
Data Source: BioPlex,STRINGDB
DISP1
Tbio
Novelty: 0.04770784
p_int: 0.824600485
p_ni: 0.175399515
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.766254574
p_ni: 0.233745426
Data Source: BioPlex
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.988
Data Source: STRINGDB
DYSF
Tbio
Novelty: 0.00248634
Score: 0.986
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1134.02

PubMed score by year
PubTator Score  600.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: