Tbio ALDOA Fructose-bisphosphate aldolase A

Protein Summary

Description

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

Uniprot Accession IDs

• P04075
• B4DXI7
• Q6FH76
• Q6FI10
• Q96B15
• Q9BWD9
• Q9UCN2

Gene Name

• ALDOA

Ensembl ID

• ENST00000412304
• ENSP00000400452
• ENSG00000149925
• ENST00000563060
• ENSP00000455800
• ENST00000564546
• ENSP00000455917
• ENST00000564595
• ENSP00000457468
• ENST00000569545
• ENSP00000455700
• ENST00000642816
• ENSP00000496166
• ENST00000643777
• ENSP00000494188

Symbol

• ALDA
• ALDA
• GSD12
• HEL-S-87p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.99
transcription factor perturbation	0.99
disease perturbation	0.98
transcription factor	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 632   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (296)

Explore Interacting Targets

1 – 10 of 296

• See Interactions on String-DB

ALDOC

Tbio

Family:  Enzyme

Novelty:  0.01552954

p_int:  0.999998396

p_ni:  0.000001604

Score:  0.981

Data Source:  BioPlex,STRINGDB

ALDOB

Tbio

Family:  Enzyme

Novelty:  0.00856695

p_int:  0.999299076

p_ni:  0.000700924

Score:  0.818

Data Source:  BioPlex,STRINGDB

CARM1

Tchem

Family:  Epigenetic

Novelty:  0.00623937

p_int:  0.90905762

p_ni:  0.09094238

Score:  0.262

Data Source:  BioPlex,STRINGDB

GAPDH

Tchem

Family:  Enzyme

Novelty:  0.00005849

Score:  0.995

Data Source:  STRINGDB

TPI1

Tbio

Family:  Enzyme

Novelty:  0.00074652

Score:  0.99

Data Source:  STRINGDB

PFKP

Tbio

Family:  Kinase

Novelty:  0.00808684

Score:  0.979

Data Source:  STRINGDB

PKM

Tchem

Family:  Kinase

Novelty:  0.00076567

Score:  0.979

Data Source:  STRINGDB

PFKL

Tbio

Family:  Kinase

Novelty:  0.00586306

Score:  0.978

Data Source:  STRINGDB

PFKM

Tbio

Family:  Kinase

Novelty:  0.00217816

Score:  0.976

Data Source:  STRINGDB

TALDO1

Tbio

Family:  Enzyme

Novelty:  0.00208619

Score:  0.975

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Upstream (1)

1 – 1 of 1

AKR1B1

Tclin

Family:  Enzyme

KEGG Distance:  3

Common Pathways:  2

1: Fructose and mannose metabolism

2: Metabolic pathways

Pathways (55)

Reactome (12)

KEGG (7)

PathwayCommons (11)

UniProt (1)

WikiPathways (24)

Gluconeogenesis (R-HSA-70263)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gluconeogenesis	34 targets	R-HSA-70263
Reactome	Glucose metabolism	92 targets	R-HSA-70326
Reactome	Glycolysis	72 targets	R-HSA-70171
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Gluconeogenesis	34 targets	R-HSA-70263
Glucose metabolism	92 targets	R-HSA-70326
Glycolysis	72 targets	R-HSA-70171
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (36)

Functions (8)

Components (14)

Processes (14)

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1 – 8 of 8

GO Term	Evidence	Assigned by
cytoskeletal protein binding	Inferred from Direct Assay (IDA)	BHF-UCL
fructose binding	Inferred from Direct Assay (IDA)	BHF-UCL
fructose-bisphosphate aldolase activity	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
actin binding	Traceable Author Statement (TAS)	BHF-UCL
tubulin binding	Traceable Author Statement (TAS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (41)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	2	3	6		94.7
body mass index	EFO_0004340	4	4	4		94.4
mean corpuscular volume	EFO_0004526	3	2	3		94
red blood cell density measurement	EFO_0007978	2	1	2		87.3
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		87

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	6		94.7
body mass index	EFO_0004340	4		94.4
mean corpuscular volume	EFO_0004526	3		94
red blood cell density measurement	EFO_0007978	2		87.3
mean corpuscular hemoglobin concentration	EFO_0004528	1		87

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycogen storage disease
Glycolysis
Hereditary hemolytic anemia

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
alcohol consumption measurement
alcohol use disorder measurement
apolipoprotein A 1 measurement
appendicular lean mass
bipolar disorder
body height
body mass index
diastolic blood pressure
Diuretic use measurement

MGI Phenotype Find Similar Targets

No Header	No Header
limbs/digits/tail phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aldolase, fructose-bisphosphate A	VGNC:5671	454362
Macaque	aldolase, fructose-bisphosphate A		708406
Mouse	aldolase A, fructose-bisphosphate	MGI:87994	11674
Rat	aldolase, fructose-bisphosphate A	RGD:2089	24189
Horse	aldolase, fructose-bisphosphate A	VGNC:15242	100066121

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aldolase, fructose-bisphosphate A
Macaque	aldolase, fructose-bisphosphate A
Mouse	aldolase A, fructose-bisphosphate
Rat	aldolase, fructose-bisphosphate A
Horse	aldolase, fructose-bisphosphate A

Publication Statistics

PubMed Score 199.18

PubMed score by year

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PubTator Score 66.36

PubTator score by year

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Related Publications

Text Mined References (98)

GeneRif Annotations (32)

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PMID	Year	Title