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Tbio
ALDOA
Fructose-bisphosphate aldolase A

Protein Summary
Description
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412304
  • ENSP00000400452
  • ENSG00000149925
  • ENST00000563060
  • ENSP00000455800
  • ENST00000564546
  • ENSP00000455917
  • ENST00000564595
  • ENSP00000457468
  • ENST00000569545
  • ENSP00000455700
  • ENST00000642816
  • ENSP00000496166
  • ENST00000643777
  • ENSP00000494188

Symbol
  • ALDA
  • ALDA
  • GSD12
  • HEL-S-87p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
transcription factor perturbation
0.99
disease perturbation
0.98
transcription factor
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.18   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (296)
ALDOC
Tbio
Family:  Enzyme
Novelty:  0.01552954
p_int:  0.999998396
p_ni:  0.000001604
Score:  0.981
Data Source:  BioPlex,STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
p_int:  0.999299076
p_ni:  0.000700924
Score:  0.818
Data Source:  BioPlex,STRINGDB
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.90905762
p_ni:  0.09094238
Score:  0.262
Data Source:  BioPlex,STRINGDB
GAPDH
Tchem
Family:  Enzyme
Novelty:  0.00005849
Score:  0.995
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.99
Data Source:  STRINGDB
PFKP
Tbio
Family:  Kinase
Novelty:  0.00808684
Score:  0.979
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.979
Data Source:  STRINGDB
PFKL
Tbio
Family:  Kinase
Novelty:  0.00586306
Score:  0.978
Data Source:  STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
Score:  0.976
Data Source:  STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
Score:  0.975
Data Source:  STRINGDB
Pathways (55)
Gluconeogenesis (R-HSA-70263)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
3
6
94.7
body mass index
4
4
4
94.4
mean corpuscular volume
3
2
3
94
red blood cell density measurement
2
1
2
87.3
mean corpuscular hemoglobin concentration
1
1
1
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
6
94.7
body mass index
4
94.4
mean corpuscular volume
3
94
red blood cell density measurement
2
87.3
mean corpuscular hemoglobin concentration
1
87
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate A
VGNC:5671
454362
Macaque
aldolase, fructose-bisphosphate A
708406
Mouse
MGI:87994
11674
Rat
RGD:2089
24189
Horse
aldolase, fructose-bisphosphate A
VGNC:15242
100066121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate A
Macaque
aldolase, fructose-bisphosphate A
Mouse
Rat
Horse
aldolase, fructose-bisphosphate A
Publication Statistics
PubMed Score 199.18
PubMed score by year
PubTator Score 66.36
PubTator score by year
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Related Publications
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PMID
Year
Title