ALDOA
Fructose-bisphosphate aldolase A
Protein Summary
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
- ENST00000412304
- ENSP00000400452
- ENSG00000149925
- ENST00000563060
- ENSP00000455800
- ENST00000564546
- ENSP00000455917
- ENST00000564595
- ENSP00000457468
- ENST00000569545
- ENSP00000455700
- ENST00000642816
- ENSP00000496166
- ENST00000643777
- ENSP00000494188
- ALDA
- ALDA
- GSD12
- HEL-S-87p
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein complex | 1 | ||
interacting protein | 0.99 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.98 | ||
transcription factor | 0.97 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.09 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 632 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.09 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 632 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 1 | 2 | 87.4 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 53 | |||||
platelet crit | 1 | 1 | 1 | 36.5 | |||||
risk-taking behaviour | 1 | 1 | 1 | 9.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 87.4 | |||||
eosinophil percentage of leukocytes | 1 | 53 | |||||
platelet crit | 1 | 36.5 | |||||
risk-taking behaviour | 1 | 9.8 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aldolase, fructose-bisphosphate A | VGNC:5671 | 454362 | |||||
Macaque | aldolase, fructose-bisphosphate A | 708406 | ||||||
Mouse | MGI:87994 | 11674 | ||||||
Rat | RGD:2089 | 24189 | ||||||
Horse | aldolase, fructose-bisphosphate A | VGNC:15242 | 100066121 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aldolase, fructose-bisphosphate A | |||||
Macaque | aldolase, fructose-bisphosphate A | |||||
Mouse | ||||||
Rat | ||||||
Horse | aldolase, fructose-bisphosphate A | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (55)
Reactome (12)
KEGG (7)
PathwayCommons (11)
UniProt (1)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Hemostasis | ||||
Immune System | ||||
Gene Ontology Terms (36)
Functions (8)
Components (14)
Processes (14)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Protein-Protein Interactions (296)
1 – 10 of 296
ALDOC
Family: Enzyme
Novelty: 0.01552954
p_int: 0.999998396
p_ni: 0.000001604
Score: 0.981
Data Source: BioPlex,STRINGDB
ALDOB
Family: Enzyme
Novelty: 0.00856695
p_int: 0.999299076
p_ni: 0.000700924
Score: 0.818
Data Source: BioPlex,STRINGDB
CARM1
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.90905762
p_ni: 0.09094238
Score: 0.262
Data Source: BioPlex,STRINGDB
GAPDH
Family: Enzyme
Novelty: 0.00005849
Score: 0.995
Data Source: STRINGDB
TPI1
Family: Enzyme
Novelty: 0.00074652
Score: 0.99
Data Source: STRINGDB
PFKP
Family: Kinase
Novelty: 0.00808684
Score: 0.979
Data Source: STRINGDB
PKM
Family: Kinase
Novelty: 0.00076567
Score: 0.979
Data Source: STRINGDB
PFKL
Family: Kinase
Novelty: 0.00586306
Score: 0.978
Data Source: STRINGDB
PFKM
Family: Kinase
Novelty: 0.00217816
Score: 0.976
Data Source: STRINGDB
TALDO1
Family: Enzyme
Novelty: 0.00208619
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score 188.09
PubMed score by year
PubTator Score 66.36
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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