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Tchem
PROC
Vitamin K-dependent protein C

Protein Summary
Description
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234071
  • ENSP00000234071
  • ENSG00000115718

Symbol
  • PC
  • APC
  • PROC1
  • THPH3
  • THPH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological term
0.99
gene perturbation
0.84
cell type or tissue
0.7
chemical
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.46   (req: < 5)
Gene RIFs: 257   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.46   (req: >= 5)
Gene RIFs: 257   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
3
3
3
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
3
93.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein C, inactivator of coagulation factors Va and VIIIa
VGNC:2789
459593
Mouse
MGI:97771
19123
Rat
RGD:3411
25268
Dog
protein C, inactivator of coagulation factors Va and VIIIa
VGNC:45006
476104
Horse
protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein C, inactivator of coagulation factors Va and VIIIa
Mouse
Rat
Dog
protein C, inactivator of coagulation factors Va and VIIIa
Horse
protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451]
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04070-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (190)
1 – 10 of 190
EPHA6
Tchem
Family:  Kinase
Novelty:  0.02713974
p_int:  0.992125285
p_ni:  0.00124721
p_wrong:  0.006627504
Score:  0.275
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.976834912
p_ni:  0.011228664
p_wrong:  0.011936424
Score:  0.171
Data Source:  BioPlex,STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.94431522
p_ni:  0.007046646
p_wrong:  0.048638134
Score:  0.173
Data Source:  BioPlex,STRINGDB
PDF
Tchem
Family:  Enzyme
Novelty:  0.02477934
p_int:  0.907785041
p_ni:  0.092214959
Score:  0.163
Data Source:  BioPlex,STRINGDB
PROS1
Tbio
Novelty:  0.00275184
p_int:  0.789299317
p_ni:  0.210700299
p_wrong:  3.84e-7
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
p_int:  0.771907203
p_ni:  0.091399776
p_wrong:  0.136693022
Data Source:  BioPlex
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.996
Data Source:  Reactome,STRINGDB
PROCR
Tbio
Novelty:  0.00197724
Score:  0.994
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.989
Data Source:  STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.982
Data Source:  STRINGDB
Publication Statistics
PubMed Score  233.46

PubMed score by year
PubTator Score  1590.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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