PROC
Vitamin K-dependent protein C
Protein Summary
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
- ENST00000234071
- ENSP00000234071
- ENSG00000115718
- PC
- APC
- PROC1
- THPH3
- THPH4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological term | 0.99 | ||
gene perturbation | 0.84 | ||
cell type or tissue | 0.7 | ||
chemical | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.35 (req: < 5)
Gene RIFs: 290 (req: <= 3)
Antibodies: 670 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.35 (req: >= 5)
Gene RIFs: 290 (req: > 3)
Antibodies: 670 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 52
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0