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Tchem
FUCA1
Tissue alpha-L-fucosidase

Protein Summary
Description
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374479
  • ENSP00000363603
  • ENSG00000179163

Symbol
  • FUCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.92
kinase perturbation
0.88
virus perturbation
0.88
histone modification site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.31   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.31   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (45)
CHEMBL69294
Rendered image for CHEMBL69294
1-deoxyfuconojirimycin
Rendered image for 1-deoxyfuconojirimycin
CHEMBL114103
Rendered image for CHEMBL114103
CHEMBL87463
Rendered image for CHEMBL87463
CHEMBL85773
Rendered image for CHEMBL85773
CHEMBL2442786
Rendered image for CHEMBL2442786
CHEMBL2442788
Rendered image for CHEMBL2442788
Protein-Protein Interactions (147)
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
p_int:  0.999999757
p_ni:  2.42e-7
Score:  0.552
Data Source:  BioPlex,STRINGDB
PRKD1
Tchem
Family:  Kinase
Novelty:  0.00128927
p_int:  0.999997161
p_ni:  5.66e-7
p_wrong:  0.000002273
Score:  0.45
Data Source:  BioPlex,STRINGDB
CHCHD5
Tbio
Novelty:  0.16304141
p_int:  0.999996983
p_ni:  0.000001896
p_wrong:  0.000001121
Score:  0.517
Data Source:  BioPlex,STRINGDB
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.9803894
p_ni:  0.0196106
Score:  0.21
Data Source:  BioPlex,STRINGDB
TIPRL
Tbio
Novelty:  0.01885339
p_int:  0.966179706
p_ni:  0.033820283
p_wrong:  1.1e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
FUCA2
Tchem
Family:  Enzyme
Novelty:  0.02259158
p_int:  0.910302068
p_ni:  0.089697932
Score:  0.921
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.900155734
p_ni:  0.028337038
p_wrong:  0.071507227
Score:  0.326
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.987
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.961
Data Source:  STRINGDB
GLA
Tclin
Family:  Enzyme
Novelty:  0.00075604
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Immune System
Innate Immune System
Metabolism of proteins
N-glycan antennae elongation in the medial/trans-Golgi
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
92.4
eosinophil count
3
3
3
91.9
reticulocyte measurement
3
2
3
90.5
eosinophil percentage of leukocytes
2
2
2
85.5
lymphocyte count
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
92.4
eosinophil count
3
91.9
reticulocyte measurement
3
90.5
eosinophil percentage of leukocytes
2
85.5
lymphocyte count
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-L-fucosidase 1
VGNC:14873
469222
Macaque
alpha-L-fucosidase 1
710993
Mouse
MGI:95593
71665
Rat
RGD:2636
24375
Dog
alpha-L-fucosidase 1
VGNC:41005
403929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-L-fucosidase 1
Macaque
alpha-L-fucosidase 1
Mouse
Rat
Dog
alpha-L-fucosidase 1
Publication Statistics
PubMed Score 113.31
PubMed score by year
PubTator Score 142.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title