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Tchem
PLA2G1B
Phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308366
  • ENSP00000312286
  • ENSG00000170890

Symbol
  • PLA2
  • PLA2A
  • PPLA2
  • PLA2
  • PLA2A
  • PPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
0.95
molecular function
0.84
PubMedID
0.75
gene perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.89   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 983.89   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (61)
1 – 10 of 61
CHEMBL148674
chemical structure image
CHEMBL148649
chemical structure image
CHEMBL515637,CHEMBL435488
chemical structure image
CHEMBL208315
chemical structure image
CHEMBL346196
chemical structure image
CHEMBL514841
chemical structure image
CHEMBL332993
chemical structure image
CHEMBL357979
chemical structure image
CHEMBL345986
chemical structure image
CHEMBL433701
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IB
VGNC:5533
742280
Macaque
phospholipase A2 group IB
696712
Mouse
MGI:101842
18778
Rat
RGD:61949
29526
Dog
phospholipase A2 group IB
VGNC:44622
404011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IB
Macaque
phospholipase A2 group IB
Mouse
Rat
Dog
phospholipase A2 group IB
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04054-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Gene Ontology Terms (46)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (166)
1 – 10 of 166
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.97
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.94
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.937
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.93
Data Source: STRINGDB
PLA2G6
Tchem
Family: Enzyme
Novelty: 0.00262569
Score: 0.92
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.899
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.879
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.87
Data Source: STRINGDB
ALOX12
Tchem
Family: Enzyme
Novelty: 0.00287761
Score: 0.868
Data Source: STRINGDB
PLA2R1
Tbio
Family: Enzyme
Novelty: 0.00355963
Score: 0.86
Data Source: STRINGDB
Publication Statistics
PubMed Score  983.89

PubMed score by year
PubTator Score  4511.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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