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Tchem
PLA2G1B
Phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308366
  • ENSP00000312286
  • ENSG00000170890

Symbol
  • PLA2
  • PLA2A
  • PPLA2
  • PLA2
  • PLA2A
  • PPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
0.95
molecular function
0.84
PubMedID
0.75
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.04   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.04   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (69)
varespladib
Rendered image for varespladib
CHEMBL515637
Rendered image for CHEMBL515637
CHEMBL148649
Rendered image for CHEMBL148649
CHEMBL208315
Rendered image for CHEMBL208315
CHEMBL332993
Rendered image for CHEMBL332993
CHEMBL514841
Rendered image for CHEMBL514841
CHEMBL346196
Rendered image for CHEMBL346196
CHEMBL357979
Rendered image for CHEMBL357979
CHEMBL436456
Rendered image for CHEMBL436456
CHEMBL345986
Rendered image for CHEMBL345986
Protein-Protein Interactions (166)
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.97
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.94
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.937
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.93
Data Source:  STRINGDB
PLA2G6
Tchem
Family:  Enzyme
Novelty:  0.00262569
Score:  0.92
Data Source:  STRINGDB
PLA2G15
Tbio
Family:  Enzyme
Novelty:  0.01546393
Score:  0.899
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.879
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.87
Data Source:  STRINGDB
ALOX12
Tchem
Family:  Enzyme
Novelty:  0.00287761
Score:  0.868
Data Source:  STRINGDB
PLA2R1
Tbio
Family:  Enzyme
Novelty:  0.00355963
Score:  0.86
Data Source:  STRINGDB
Pathways (77)
Acyl chain remodelling of PC (R-HSA-1482788)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
7
7
93.2
Left ventricular mass to end-diastolic volume ratio
1
1
1
40.7
mean corpuscular volume
1
1
1
39.6
platelet count
1
1
1
31.4
appendicular lean mass
1
2
2
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
93.2
Left ventricular mass to end-diastolic volume ratio
1
40.7
mean corpuscular volume
1
39.6
platelet count
1
31.4
appendicular lean mass
2
29.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IB
VGNC:5533
742280
Macaque
phospholipase A2 group IB
696712
Mouse
MGI:101842
18778
Rat
RGD:61949
29526
Dog
phospholipase A2 group IB
VGNC:44622
404011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IB
Macaque
phospholipase A2 group IB
Mouse
Rat
Dog
phospholipase A2 group IB
Publication Statistics
PubMed Score 1004.04
PubMed score by year
PubTator Score 4511.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title