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Tchem
DNTT
DNA nucleotidylexotransferase

Protein Summary
Description
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371174
  • ENSP00000360216
  • ENSG00000107447
  • ENST00000630152
  • ENSP00000486733

Symbol
  • TDT
  • TDT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.68
molecular function
0.6
gene perturbation
0.55
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2504.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2504.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (197)
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.977
Data Source:  STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.974
Data Source:  STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
Score:  0.96
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.956
Data Source:  STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.942
Data Source:  STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
Score:  0.928
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.902
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.897
Data Source:  STRINGDB
ANXA5
Tbio
Novelty:  0.00007584
Score:  0.816
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.801
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
50.2
substance abuse
1
1
1
50.2
antisocial behaviour measurement
1
1
1
50.2
mean corpuscular volume
1
1
1
35.6
gut microbiome measurement
1
1
1
31.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
50.2
substance abuse
1
50.2
antisocial behaviour measurement
1
50.2
mean corpuscular volume
1
35.6
gut microbiome measurement
1
31.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA nucleotidylexotransferase
VGNC:1568
466167
Macaque
DNA nucleotidylexotransferase
704482
Mouse
MGI:98659
21673
Rat
RGD:1305054
294051
Dog
DNA nucleotidylexotransferase
VGNC:40039
486815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA nucleotidylexotransferase
Macaque
DNA nucleotidylexotransferase
Mouse
Rat
Dog
DNA nucleotidylexotransferase
Publication Statistics
PubMed Score 2504.34
PubMed score by year
PubTator Score 1837.19
PubTator score by year
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Related Publications
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PMID
Year
Title