Protein Classes
Protein Summary
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. ...more
- ENST00000241052
- ENSP00000241052
- ENSG00000121691
- ENST00000648322
- ENSP00000496910
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
interacting protein | 0.96 | ||
biological process | 0.95 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 491.82 (req: < 5)
Gene RIFs: 243 (req: <= 3)
Antibodies: 856 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 491.82 (req: >= 5)
Gene RIFs: 243 (req: > 3)
Antibodies: 856 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (15)
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (335)
Reactome (13)
KEGG (9)
PathwayCommons (4)
WikiPathways (309)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Gene Ontology Terms (65)
Functions (11)
Components (16)
Processes (38)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (623)
1 – 10 of 623
SOD2
Family: Enzyme
Novelty: 0.00084288
Score: 0.998
Data Source: STRINGDB
SOD1
Family: Enzyme
Novelty: 0.00039653
Score: 0.996
Data Source: STRINGDB
SOD3
Family: Enzyme
Novelty: 0.0015758
Score: 0.989
Data Source: STRINGDB
GSR
Family: Enzyme
Novelty: 0.00040107
Score: 0.987
Data Source: STRINGDB
SCP2
Novelty: 0.00183736
Score: 0.986
Data Source: STRINGDB
ACOX1
Family: Enzyme
Novelty: 0.00473427
Score: 0.986
Data Source: STRINGDB
HSD17B4
Novelty: 0.00547499
Score: 0.979
Data Source: STRINGDB
DAO
Family: Enzyme
Novelty: 0.00414923
Score: 0.974
Data Source: STRINGDB
HAO1
Family: Enzyme
Novelty: 0.00054723
Score: 0.972
Data Source: STRINGDB
AKT1
Family: Kinase
Novelty: 0.00003185
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score 491.82
PubMed score by year
PubTator Score 8525.26
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword