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Tbio
CAT
Catalase

Protein Summary
Description
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241052
  • ENSP00000241052
  • ENSG00000121691
  • ENST00000648322
  • ENSP00000496910
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
disease perturbation
0.99
transcription factor perturbation
0.99
interacting protein
0.96
biological process
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.82   (req: < 5)
Gene RIFs: 243   (req: <= 3)
Antibodies: 856   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.82   (req: >= 5)
Gene RIFs: 243   (req: > 3)
Antibodies: 856   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
catalase
VGNC:3174
451116
Macaque
catalase
717406
Mouse
MGI:88271
12359
Rat
RGD:2279
24248
Dog
catalase
403474
Species
Name
OMA
EggNOG
Inparanoid
Chimp
catalase
Macaque
catalase
Mouse
Rat
Dog
catalase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04040-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (335)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (623)
1 – 10 of 623
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.998
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.996
Data Source: STRINGDB
SOD3
Tbio
Family: Enzyme
Novelty: 0.0015758
Score: 0.989
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.987
Data Source: STRINGDB
SCP2
Tchem
Novelty: 0.00183736
Score: 0.986
Data Source: STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.986
Data Source: STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.979
Data Source: STRINGDB
DAO
Tchem
Family: Enzyme
Novelty: 0.00414923
Score: 0.974
Data Source: STRINGDB
HAO1
Tchem
Family: Enzyme
Novelty: 0.00054723
Score: 0.972
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  491.82

PubMed score by year
PubTator Score  8525.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer