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Tclin
HMGCR
3-hydroxy-3-methylglutaryl-coenzyme A reductase

Protein Summary
Description
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287936
  • ENSP00000287936
  • ENSG00000113161
  • ENST00000343975
  • ENSP00000340816
  • ENST00000511206
  • ENSP00000426745

Symbol
  • LDLCQ3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
1
protein domain
0.99
chemical
0.93
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1869.86   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1869.86   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 208
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
8
22
2.8
99.6
total cholesterol measurement
10
7
15
3.2
99.4
apolipoprotein B measurement
1
1
1
71.3
high density lipoprotein cholesterol measurement
1
1
2
66.5
triglyceride measurement
1
1
2
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
22
2.8
99.6
total cholesterol measurement
15
3.2
99.4
apolipoprotein B measurement
1
71.3
high density lipoprotein cholesterol measurement
2
66.5
triglyceride measurement
2
66.5
Protein Data Bank (22)
1 – 5 of 22
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (57)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (243)
1 – 10 of 243
PTCHD3
Tbio
Novelty: 0.00081643
p_int: 0.992128034
p_ni: 0.007871966
Data Source: BioPlex
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
p_int: 0.97357521
p_ni: 0.026424789
Score: 0.187
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.942366167
p_ni: 0.057633833
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.931968933
p_ni: 0.068031067
Data Source: BioPlex
PTGIR
Tclin
Family: GPCR
Novelty: 0.0091906
p_int: 0.91768648
p_ni: 0.08231352
Score: 0.159
Data Source: BioPlex,STRINGDB
CD209
Tbio
Novelty: 0.001172
p_int: 0.91367529
p_ni: 0.08632471
Score: 0.345
Data Source: BioPlex,STRINGDB
ACVR1C
Tbio
Family: Kinase
Novelty: 0.01675672
p_int: 0.907917318
p_ni: 0.092082682
Data Source: BioPlex
KCNS3
Tclin
Family: IC
Novelty: 0.05882087
p_int: 0.893074814
p_ni: 0.106925125
p_wrong: 6.1e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
p_int: 0.84682935
p_ni: 0.15317065
Data Source: BioPlex
OR13J1
Tdark
Family: oGPCR
Novelty: 2.15311005
p_int: 0.765481356
p_ni: 0.234518636
p_wrong: 7e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1869.86

PubMed score by year
PubTator Score  2539.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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