Protein Summary
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
- ENST00000226218
- ENSP00000226218
- ENSG00000109072
- VN
- V75
- VNT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
biological process | 0.92 | ||
interacting protein | 0.83 | ||
molecular function | 0.76 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1917.34 (req: < 5)
Gene RIFs: 104 (req: <= 3)
Antibodies: 963 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1917.34 (req: >= 5)
Gene RIFs: 104 (req: > 3)
Antibodies: 963 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (252)
GLI4
Family: TF
Novelty: 0.15339473
p_int: 0.999998906
p_ni: 1.5e-8
p_wrong: 0.000001079
Score: 0.229
Data Source: BioPlex,STRINGDB
RAI14
Novelty: 0.06291577
p_int: 0.999998049
p_ni: 0.000001926
p_wrong: 2.5e-8
Data Source: BioPlex
OTUD4
Novelty: 0.17121119
p_int: 0.999994755
p_ni: 0.000005234
p_wrong: 1.2e-8
Data Source: BioPlex
CFAP410
Novelty: 0.0143773
p_int: 0.999859626
p_ni: 0.000140354
p_wrong: 1.9e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
ZNF483
Family: TF
Novelty: 0.39891191
p_int: 0.999342814
p_ni: 0.000657177
p_wrong: 9e-9
Data Source: BioPlex
MPRIP
Family: Enzyme
Novelty: 0.03253403
p_int: 0.998519525
p_ni: 0.001480473
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (32)
Reactome (11)
KEGG (6)
PathwayCommons (7)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | ECM proteoglycans | ||||
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complement cascade | ||||
ECM proteoglycans | ||||
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (41)
Functions (8)
Components (11)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 8 | 4 | 9 | 92.8 | |||||
osteoprotegerin measurement | 2 | 1 | 2 | 86.6 | |||||
interleukin-27 measurement | 1 | 1 | 1 | 84.6 | |||||
apolipoprotein B measurement | 2 | 3 | 3 | 83 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 81.2 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 9 | 92.8 | |||||
osteoprotegerin measurement | 2 | 86.6 | |||||
interleukin-27 measurement | 1 | 84.6 | |||||
apolipoprotein B measurement | 3 | 83 | |||||
apolipoprotein A 1 measurement | 2 | 81.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vitronectin | VGNC:14218 | 738261 | |||||
Macaque | vitronectin | 708499 | ||||||
Mouse | MGI:98940 | 22370 | ||||||
Rat | RGD:3967 | 29169 | ||||||
Dog | vitronectin | 480621 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | vitronectin | |||||
Macaque | vitronectin | |||||
Mouse | ||||||
Rat | ||||||
Dog | vitronectin | |||||
Publication Statistics
PubMed Score 1917.34
PubMed score by year
PubTator Score 1821.55
PubTator score by year
Related Publications
Text Mined References (181)
GeneRif Annotations (104)
Items per page:
0 of 0
PMID | Year | Title |
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