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Tbio
VTN
Vitronectin

Protein Summary
Description
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226218
  • ENSP00000226218
  • ENSG00000109072

Symbol
  • VN
  • V75
  • VNT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
biological process
0.92
interacting protein
0.83
molecular function
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1892.3   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 963   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1892.3   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 963   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
1
5
91.9
osteoprotegerin measurement
2
1
2
87
heel bone mineral density
2
1
2
81.8
interleukin-27 measurement
1
1
1
78.6
TNF-related activation-induced cytokine measurement
1
1
1
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
91.9
osteoprotegerin measurement
2
87
heel bone mineral density
2
81.8
interleukin-27 measurement
1
78.6
TNF-related activation-induced cytokine measurement
1
73.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vitronectin
VGNC:14218
738261
Macaque
vitronectin
708499
Mouse
MGI:98940
22370
Rat
RGD:3967
29169
Dog
vitronectin
480621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vitronectin
Macaque
vitronectin
Mouse
Rat
Dog
vitronectin
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
ECM proteoglycans
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Complement cascade
ECM proteoglycans
Elastic fibre formation
Extracellular matrix organization
Immune System
Gene Ontology Terms (41)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (252)
1 – 10 of 252
UACA
Tbio
Novelty: 0.05853699
p_int: 0.999999901
p_ni: 9.9e-8
Data Source: BioPlex
TRIOBP
Tbio
Novelty: 0.04145641
p_int: 0.99999968
p_ni: 3.19e-7
p_wrong: 2e-9
Data Source: BioPlex
GLI4
Tbio
Family: TF
Novelty: 0.15339473
p_int: 0.999998906
p_ni: 1.5e-8
p_wrong: 0.000001079
Score: 0.229
Data Source: BioPlex,STRINGDB
RAI14
Tbio
Novelty: 0.06291577
p_int: 0.999998049
p_ni: 0.000001926
p_wrong: 2.5e-8
Data Source: BioPlex
OTUD4
Tbio
Novelty: 0.17121119
p_int: 0.999994755
p_ni: 0.000005234
p_wrong: 1.2e-8
Data Source: BioPlex
CFAP410
Tbio
Novelty: 0.0143773
p_int: 0.999859626
p_ni: 0.000140354
p_wrong: 1.9e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
ZNF483
Tdark
Family: TF
Novelty: 0.39891191
p_int: 0.999342814
p_ni: 0.000657177
p_wrong: 9e-9
Data Source: BioPlex
GPRIN1
Tbio
Novelty: 0.14698407
p_int: 0.999079322
p_ni: 0.000920678
Data Source: BioPlex
ZNF696
Tdark
Family: TF
Novelty: 3.49300122
p_int: 0.998529745
p_ni: 0.001470255
Data Source: BioPlex
MPRIP
Tbio
Family: Enzyme
Novelty: 0.03253403
p_int: 0.998519525
p_ni: 0.001480473
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1892.30

PubMed score by year
PubTator Score  1821.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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