Tbio VTN Vitronectin

Protein Summary

Description

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04004
• B2R7G0
• P01141
• Q9BSH7
• VN

Gene Name

• VTN

Ensembl ID

• ENST00000226218
• ENSP00000226218
• ENSG00000109072

Symbol

• VN
• V75
• VNT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
biological process	0.92
interacting protein	0.83
molecular function	0.76
protein domain	0.73

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1892.3   (req: < 5)

Gene RIFs: 104   (req: <= 3)

Antibodies: 963   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1892.3   (req: >= 5)

Gene RIFs: 104   (req: > 3)

Antibodies: 963   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	5	1	5		91.9
osteoprotegerin measurement	EFO_0005918	2	1	2		87
heel bone mineral density	EFO_0009270	2	1	2		81.8
interleukin-27 measurement	EFO_0010916	1	1	1		78.6
TNF-related activation-induced cytokine measurement	EFO_0010929	1	1	1		73.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	5		91.9
osteoprotegerin measurement	EFO_0005918	2		87
heel bone mineral density	EFO_0009270	2		81.8
interleukin-27 measurement	EFO_0010916	1		78.6
TNF-related activation-induced cytokine measurement	EFO_0010929	1		73.2

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	vitronectin	VGNC:14218	738261
Macaque	vitronectin		708499
Mouse	vitronectin	MGI:98940	22370
Rat	vitronectin	RGD:3967	29169
Dog	vitronectin		480621

Species	Name	OMA	EggNOG	Inparanoid
Chimp	vitronectin
Macaque	vitronectin
Mouse	vitronectin
Rat	vitronectin
Dog	vitronectin

Protein Structure (7 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04004-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (32)

Reactome (11)

KEGG (6)

PathwayCommons (7)

WikiPathways (8)

Complement cascade (R-HSA-166658)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178
Reactome	Elastic fibre formation	41 targets	R-HSA-1566948
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Complement cascade	133 targets	R-HSA-166658
ECM proteoglycans	56 targets	R-HSA-3000178
Elastic fibre formation	41 targets	R-HSA-1566948
Extracellular matrix organization	297 targets	R-HSA-1474244
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (41)

Functions (8)

Components (11)

Processes (22)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
integrin binding	Inferred from Direct Assay (IDA)	UniProtKB
extracellular matrix structural constituent	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
collagen binding	Inferred from Electronic Annotation (IEA)	Ensembl
extracellular matrix binding	Inferred from Electronic Annotation (IEA)	Ensembl
heparin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
polysaccharide binding	Inferred from Electronic Annotation (IEA)	InterPro
scavenger receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (252)

Explore Interacting Targets

1 – 10 of 252

• See Interactions on String-DB

UACA

Tbio

Novelty: 0.05853699

p_int: 0.999999901

p_ni: 9.9e-8

Data Source: BioPlex

TRIOBP

Tbio

Novelty: 0.04145641

p_int: 0.99999968

p_ni: 3.19e-7

p_wrong: 2e-9

Data Source: BioPlex

GLI4

Tbio

Family: TF

Novelty: 0.15339473

p_int: 0.999998906

p_ni: 1.5e-8

p_wrong: 0.000001079

Score: 0.229

Data Source: BioPlex,STRINGDB

RAI14

Tbio

Novelty: 0.06291577

p_int: 0.999998049

p_ni: 0.000001926

p_wrong: 2.5e-8

Data Source: BioPlex

OTUD4

Tbio

Novelty: 0.17121119

p_int: 0.999994755

p_ni: 0.000005234

p_wrong: 1.2e-8

Data Source: BioPlex

CFAP410

Tbio

Novelty: 0.0143773

p_int: 0.999859626

p_ni: 0.000140354

p_wrong: 1.9e-8

Score: 0.177

Data Source: BioPlex,STRINGDB

ZNF483

Tdark

Family: TF

Novelty: 0.39891191

p_int: 0.999342814

p_ni: 0.000657177

p_wrong: 9e-9

Data Source: BioPlex

GPRIN1

Tbio

Novelty: 0.14698407

p_int: 0.999079322

p_ni: 0.000920678

Data Source: BioPlex

ZNF696

Tdark

Family: TF

Novelty: 3.49300122

p_int: 0.998529745

p_ni: 0.001470255

Data Source: BioPlex

MPRIP

Tbio

Family: Enzyme

Novelty: 0.03253403

p_int: 0.998519525

p_ni: 0.001480473

p_wrong: 1e-9

Data Source: BioPlex

Publication Statistics

PubMed Score  1892.30

PubMed score by year

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PubTator Score  1821.55

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

apolipoprotein A 1 measurement
apolipoprotein B measurement
heel bone mineral density
high density lipoprotein cholesterol measurement
interleukin-27 measurement
low density lipoprotein cholesterol measurement
osteoprotegerin measurement
TNF-related activation-induced cytokine measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype