Tbio C4BPA C4b-binding protein alpha chain

Protein Summary

Description

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P04003
• Q5VVQ8
• C4bp

Gene Name

• C4BPA

Ensembl ID

• ENST00000367070
• ENSP00000356037
• ENSG00000123838

Symbol

• C4BP
• PRP
• C4BP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.65
biological term	0.58
cell line	0.52
small molecule perturbation	0.51
virus perturbation	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.39   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.39   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0