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Tdark
OPN1MW
Medium-wave-sensitive opsin 1

Protein Summary
Description
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595290
  • ENSP00000472316
  • ENSG00000268221

Symbol
  • GCP
  • CBD
  • GCP
  • GOP
  • CBBM
  • COD5
  • OPN1MW1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cellular component
0.55
phenotype
0.52
pathway
0.44
tissue sample
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
ARR3
Tbio
Novelty:  0.00575939
Score:  0.557
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.547
Data Source:  Reactome,STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.515
Data Source:  Reactome,STRINGDB
CRX
Tbio
Family:  TF
Novelty:  0.00278097
Score:  0.477
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.448
Data Source:  STRINGDB
VWC2L
Tdark
Novelty:  1.5878556
Score:  0.443
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.442
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.442
Data Source:  STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
Score:  0.44
Data Source:  STRINGDB
OR52J3
Tdark
Family:  oGPCR
Novelty:  0.83146741
Score:  0.426
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
50.6
eosinophil percentage of leukocytes
1
1
1
29.8
eosinophil count
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
50.6
eosinophil percentage of leukocytes
1
29.8
eosinophil count
1
12.3
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1097692
14539
Rat
RGD:620978
89810
Cow
opsin 1 (cone pigments), long-wave-sensitive
282293
Pig
medium-wave-sensitive opsin
494564
Anole lizard
red-sensitive opsin-like
100564371
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
opsin 1 (cone pigments), long-wave-sensitive
Pig
medium-wave-sensitive opsin
Anole lizard
red-sensitive opsin-like
Publication Statistics
PubMed Score 1.84
PubMed score by year
PubTator Score 67.03
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title