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Tbio
OPN1LW
Long-wave-sensitive opsin 1

Protein Summary
Description
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369951
  • ENSP00000358967
  • ENSG00000102076

Symbol
  • RCP
  • CBP
  • RCP
  • ROP
  • CBBM
  • COD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
gene perturbation
0.62
cellular component
0.57
pathway
0.51
virus perturbation
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.64   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.64   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
23
monocyte count
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
23
monocyte count
1
23
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
opsin 1 (cone pigments), long-wave-sensitive
403778
Horse
opsin 1 (cone pigments), long-wave-sensitive
100033892
Opossum
opsin 1 (cone pigments), long-wave-sensitive
100029592
Platypus
opsin 1 (cone pigments), long-wave-sensitive
100048938
Xenopus
opsin 1 (cone pigments), long-wave-sensitive
XB-GENE-955009
100124917
Species
Name
OMA
EggNOG
Inparanoid
Dog
opsin 1 (cone pigments), long-wave-sensitive
Horse
opsin 1 (cone pigments), long-wave-sensitive
Opossum
opsin 1 (cone pigments), long-wave-sensitive
Platypus
opsin 1 (cone pigments), long-wave-sensitive
Xenopus
opsin 1 (cone pigments), long-wave-sensitive
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04000-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (55)
1 – 10 of 55
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.951
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.938
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.932
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.926
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.921
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.917
Data Source: Reactome,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.917
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.917
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.916
Data Source: STRINGDB
OPN5
Tbio
Family: GPCR
Novelty: 0.02890415
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  309.64

PubMed score by year
PubTator Score  88.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer