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Tbio
OPN1SW
Short-wave-sensitive opsin 1

Protein Summary
Description
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249389
  • ENSP00000249389
  • ENSG00000128617

Symbol
  • BCP
  • BCP
  • BOP
  • CBT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cell type or tissue
0.75
protein domain
0.73
disease perturbation
0.62
pathway
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.97   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.97   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.975
Data Source:  Reactome,STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.961
Data Source:  Reactome,STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.943
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.942
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.929
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.928
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.927
Data Source:  Reactome,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.922
Data Source:  STRINGDB
GNG11
Tbio
Novelty:  0.10721743
Score:  0.922
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
2
4
89.8
self reported educational attainment
3
2
3
89.6
cognitive function measurement
3
1
3
75.4
electrocardiography
1
1
5
55.2
1
1
0
1.2
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
89.8
self reported educational attainment
3
89.6
cognitive function measurement
3
75.4
electrocardiography
5
55.2
0
1.2
51.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opsin 1, short wave sensitive
VGNC:8710
472508
Mouse
MGI:99438
12057
Rat
RGD:621033
81644
Dog
opsin 1, short wave sensitive
VGNC:44129
482267
Horse
opsin 1, short wave sensitive
VGNC:21040
100071755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opsin 1, short wave sensitive
Mouse
Rat
Dog
opsin 1, short wave sensitive
Horse
opsin 1, short wave sensitive
Publication Statistics
PubMed Score 149.97
PubMed score by year
PubTator Score 287.64
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title