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Tbio
SLPI
Antileukoproteinase

Protein Summary
Description
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). This gene enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338380
  • ENSP00000342082
  • ENSG00000124107

Symbol
  • WAP4
  • WFDC4
  • ALP
  • MPI
  • ALK1
  • BLPI
  • HUSI
  • WAP4
  • WFDC4
  • HUSI-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
0.98
disease
0.9
disease perturbation
0.87
small molecule perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.07   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.07   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretory leukocyte peptidase inhibitor
VGNC:14300
740668
Mouse
MGI:109297
20568
Rat
RGD:9143414
103694893
Dog
secretory leukocyte peptidase inhibitor
VGNC:49651
100127207
Horse
antileukoproteinase
100070893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretory leukocyte peptidase inhibitor
Mouse
Rat
Dog
secretory leukocyte peptidase inhibitor
Horse
antileukoproteinase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (127)
1 – 10 of 127
TRIM11
Tbio
Family: Enzyme
Novelty: 0.02243955
p_int: 0.987788713
p_ni: 0.012211277
p_wrong: 1e-8
Data Source: BioPlex
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.997
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.974
Data Source: STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.964
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.941
Data Source: STRINGDB
LYZ
Tbio
Family: Enzyme
Novelty: 0.00151342
Score: 0.939
Data Source: STRINGDB
BPI
Tbio
Novelty: 0.00229665
Score: 0.939
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.935
Data Source: STRINGDB
MMP8
Tchem
Family: Enzyme
Novelty: 0.00105859
Score: 0.925
Data Source: STRINGDB
PGLYRP1
Tbio
Novelty: 0.00231527
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  589.07

PubMed score by year
PubTator Score  517.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer