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Tchem
MMP1
Interstitial collagenase

Protein Summary
Description
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315274
  • ENSP00000322788
  • ENSG00000196611

Symbol
  • CLG
  • CLG
  • CLGN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
1
gene perturbation
1
protein domain
1
chemical
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3232.19   (req: < 5)
Gene RIFs: 727   (req: <= 3)
Antibodies: 1051   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3232.19   (req: >= 5)
Gene RIFs: 727   (req: > 3)
Antibodies: 1051   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1462
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
2
3
3
98.1
blood protein measurement
1
3
3
97.8
matrix metalloproteinase measurement
1
3
3
96.7
matrix metalloproteinase 10 measurement
1
1
1
49.5
matrix metalloproteinase 12 measurement
1
1
1
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
3
98.1
blood protein measurement
3
97.8
matrix metalloproteinase measurement
3
96.7
matrix metalloproteinase 10 measurement
1
49.5
matrix metalloproteinase 12 measurement
1
46
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 1
VGNC:1097
451510
Macaque
matrix metallopeptidase 1
703653
Mouse
MGI:1933847
83996
Rat
RGD:1307917
300339
Dog
matrix metallopeptidase 1
VGNC:43273
489428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 1
Macaque
matrix metallopeptidase 1
Mouse
Rat
Dog
matrix metallopeptidase 1
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03956-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (44)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Collagen degradation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Basigin interactions
Cell surface interactions at the vascular wall
Collagen degradation
Cytokine Signaling in Immune system
Protein-Protein Interactions (203)
1 – 10 of 203
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.994
Data Source:  STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.984
Data Source:  Reactome,STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.98
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.966
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.961
Data Source:  Reactome,STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.96
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.959
Data Source:  Reactome,STRINGDB
CMA1
Tchem
Family:  Enzyme
Novelty:  0.00091144
Score:  0.953
Data Source:  STRINGDB
MMP3
Tchem
Novelty:  0.00041675
Score:  0.953
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.945
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  3232.19

PubMed score by year
PubTator Score  3100.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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