Protein Summary
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- ENST00000264690
- ENSP00000264690
- ENSG00000164344
- KLK3
- PKK
- PPK
- KLK3
- PKKD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.94 | ||
protein domain | 0.92 | ||
gene perturbation | 0.67 | ||
disease | 0.58 | ||
biological process | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 837.38 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 358 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 837.38 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 358 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 833
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (833)
Protein-Protein Interactions (115)
GPHN
Novelty: 0.0020752
p_int: 0.999519389
p_ni: 0.000480612
Score: 0.332
Data Source: BioPlex,STRINGDB
ZBTB1
Family: TF
Novelty: 0.33667235
p_int: 0.998765403
p_ni: 0.000766832
p_wrong: 0.000467766
Score: 0.199
Data Source: BioPlex,STRINGDB
NID2
Novelty: 0.01638372
p_int: 0.905643194
p_ni: 0.070566413
p_wrong: 0.023790393
Data Source: BioPlex
TOR3A
Novelty: 0.11588309
p_int: 0.898464334
p_ni: 0.101535571
p_wrong: 9.5e-8
Data Source: BioPlex
STAG1
Novelty: 0.00122511
p_int: 0.896047127
p_ni: 0.103493023
p_wrong: 0.00045985
Data Source: BioPlex
NCAPH
Novelty: 0.01598076
p_int: 0.8167766
p_ni: 0.183223401
Score: 0.282
Data Source: BioPlex,STRINGDB
CNOT2
Novelty: 0.01886737
p_int: 0.755826184
p_ni: 0.244173816
Score: 0.254
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 7 | 1 | 1.2 | 99 | |||||
blood metabolite measurement | 2 | 3 | 3 | 95.6 | |||||
partial thromboplastin time | 1 | 3 | 3 | 92.2 | |||||
serum metabolite measurement | 2 | 2 | 3 | 89 | |||||
factor XI measurement | 1 | 1 | 1 | 88.1 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.2 | 99 | |||||
blood metabolite measurement | 3 | 95.6 | |||||
partial thromboplastin time | 3 | 92.2 | |||||
serum metabolite measurement | 3 | 89 | |||||
factor XI measurement | 1 | 88.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | kallikrein B1 | 696639 | ||||||
Mouse | MGI:5804868 | |||||||
Rat | RGD:67382 | 25048 | ||||||
Dog | kallikrein B1 | VGNC:42484 | 475624 | |||||
Horse | kallikrein B1 | VGNC:19490 | 100056650 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | kallikrein B1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kallikrein B1 | |||||
Horse | kallikrein B1 | |||||
Publication Statistics
PubMed Score 837.38
PubMed score by year
PubTator Score 222.20
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (30)
Items per page:
0 of 0
PMID | Year | Title |
|---|