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Tclin
KLKB1
Plasma kallikrein

Protein Classes
Protein Summary
Description
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264690
  • ENSP00000264690
  • ENSG00000164344

Symbol
  • KLK3
  • PKK
  • PPK
  • KLK3
  • PKKD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.94
protein domain
0.92
gene perturbation
0.67
disease
0.58
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 752.51   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 752.51   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 759
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (759)
1 – 10 of 759
CHEMBL96433
chemical structure image
CHEMBL176140,CHEMBL559015
chemical structure image
CHEMBL2016868
chemical structure image
CHEMBL2016870
chemical structure image
CHEMBL2016869
chemical structure image
CHEMBL3660185
chemical structure image
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (115)
1 – 10 of 115
GPHN
Tbio
Novelty: 0.00317968
p_int: 0.999519389
p_ni: 0.000480612
Score: 0.332
Data Source: BioPlex,STRINGDB
ZBTB1
Tbio
Family: TF
Novelty: 0.16878768
p_int: 0.998765403
p_ni: 0.000766832
p_wrong: 0.000467766
Score: 0.199
Data Source: BioPlex,STRINGDB
FBN2
Tbio
Novelty: 0.00189782
p_int: 0.968836973
p_ni: 0.031163027
Data Source: BioPlex
NID2
Tbio
Novelty: 0.02089229
p_int: 0.905643194
p_ni: 0.070566413
p_wrong: 0.023790393
Data Source: BioPlex
TOR3A
Tbio
Novelty: 0.00717131
p_int: 0.898464334
p_ni: 0.101535571
p_wrong: 9.5e-8
Data Source: BioPlex
STAG1
Tbio
Novelty: 0.00325752
p_int: 0.896047127
p_ni: 0.103493023
p_wrong: 0.00045985
Data Source: BioPlex
NCAPH
Tbio
Novelty: 0.02431484
p_int: 0.8167766
p_ni: 0.183223401
Score: 0.282
Data Source: BioPlex,STRINGDB
CNOT2
Tbio
Novelty: 0.00141101
p_int: 0.755826184
p_ni: 0.244173816
Score: 0.254
Data Source: BioPlex,STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.995
Data Source: Reactome,STRINGDB
SERPING1
Tbio
Family: Enzyme
Novelty: 0.00076515
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  752.51

PubMed score by year
PubTator Score  222.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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