Protein Classes
Protein Summary
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- ENST00000264690
- ENSP00000264690
- ENSG00000164344
- KLK3
- PKK
- PPK
- KLK3
- PKKD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.94 | ||
protein domain | 0.92 | ||
gene perturbation | 0.67 | ||
disease | 0.58 | ||
biological process | 0.57 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 752.51 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 358 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 752.51 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 358 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 759
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Active Ligands (759)
1 – 10 of 759
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (11)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Gene Ontology Terms (13)
Functions (1)
Components (4)
Processes (8)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (115)
1 – 10 of 115
GPHN
Novelty: 0.00317968
p_int: 0.999519389
p_ni: 0.000480612
Score: 0.332
Data Source: BioPlex,STRINGDB
ZBTB1
Family: TF
Novelty: 0.16878768
p_int: 0.998765403
p_ni: 0.000766832
p_wrong: 0.000467766
Score: 0.199
Data Source: BioPlex,STRINGDB
FBN2
Novelty: 0.00189782
p_int: 0.968836973
p_ni: 0.031163027
Data Source: BioPlex
NID2
Novelty: 0.02089229
p_int: 0.905643194
p_ni: 0.070566413
p_wrong: 0.023790393
Data Source: BioPlex
TOR3A
Novelty: 0.00717131
p_int: 0.898464334
p_ni: 0.101535571
p_wrong: 9.5e-8
Data Source: BioPlex
STAG1
Novelty: 0.00325752
p_int: 0.896047127
p_ni: 0.103493023
p_wrong: 0.00045985
Data Source: BioPlex
NCAPH
Novelty: 0.02431484
p_int: 0.8167766
p_ni: 0.183223401
Score: 0.282
Data Source: BioPlex,STRINGDB
CNOT2
Novelty: 0.00141101
p_int: 0.755826184
p_ni: 0.244173816
Score: 0.254
Data Source: BioPlex,STRINGDB
KNG1
Novelty: 0.00008572
Score: 0.995
Data Source: Reactome,STRINGDB
SERPING1
Family: Enzyme
Novelty: 0.00076515
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 752.51
PubMed score by year
PubTator Score 222.2
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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