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Tclin
KLKB1
Plasma kallikrein

Protein Summary
Description
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264690
  • ENSP00000264690
  • ENSG00000164344

Symbol
  • KLK3
  • PKK
  • PPK
  • KLK3
  • PKKD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.94
protein domain
0.92
gene perturbation
0.67
disease
0.58
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.38   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.38   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 833
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (833)
CHEMBL4642845
Rendered image for CHEMBL4642845
CHEMBL4647925
Rendered image for CHEMBL4647925
CHEMBL4643449
Rendered image for CHEMBL4643449
CHEMBL4635912
Rendered image for CHEMBL4635912
CHEMBL96433
Rendered image for CHEMBL96433
CHEMBL4517343
Rendered image for CHEMBL4517343
CHEMBL4558285
Rendered image for CHEMBL4558285
US8598206, Table 6, 2
Rendered image for US8598206, Table 6, 2
US8598206, Table 6, 24
Rendered image for US8598206, Table 6, 24
Protein-Protein Interactions (115)
GPHN
Tbio
Novelty:  0.0020752
p_int:  0.999519389
p_ni:  0.000480612
Score:  0.332
Data Source:  BioPlex,STRINGDB
ZBTB1
Tbio
Family:  TF
Novelty:  0.33667235
p_int:  0.998765403
p_ni:  0.000766832
p_wrong:  0.000467766
Score:  0.199
Data Source:  BioPlex,STRINGDB
FBN2
Tbio
Novelty:  0.00549053
p_int:  0.968836973
p_ni:  0.031163027
Data Source:  BioPlex
NID2
Tbio
Novelty:  0.01638372
p_int:  0.905643194
p_ni:  0.070566413
p_wrong:  0.023790393
Data Source:  BioPlex
TOR3A
Tbio
Novelty:  0.11588309
p_int:  0.898464334
p_ni:  0.101535571
p_wrong:  9.5e-8
Data Source:  BioPlex
STAG1
Tbio
Novelty:  0.00122511
p_int:  0.896047127
p_ni:  0.103493023
p_wrong:  0.00045985
Data Source:  BioPlex
NCAPH
Tbio
Novelty:  0.01598076
p_int:  0.8167766
p_ni:  0.183223401
Score:  0.282
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.755826184
p_ni:  0.244173816
Score:  0.254
Data Source:  BioPlex,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.995
Data Source:  Reactome,STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.975
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
7
1
1.2
99
blood metabolite measurement
2
3
3
95.6
partial thromboplastin time
1
3
3
92.2
serum metabolite measurement
2
2
3
89
factor XI measurement
1
1
1
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
99
blood metabolite measurement
3
95.6
partial thromboplastin time
3
92.2
serum metabolite measurement
3
89
factor XI measurement
1
88.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kallikrein B1
696639
Mouse
MGI:5804868
Rat
RGD:67382
25048
Dog
kallikrein B1
VGNC:42484
475624
Horse
kallikrein B1
VGNC:19490
100056650
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kallikrein B1
Mouse
Rat
Dog
kallikrein B1
Horse
kallikrein B1
Publication Statistics
PubMed Score 837.38
PubMed score by year
PubTator Score 222.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title