Tclin KLKB1 Plasma kallikrein

Protein Summary

Description

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P03952
• A6NH96
• B2R8H9
• Q17RE8
• Q17RE9
• Q4W5C3

Gene Name

• KLKB1

Ensembl ID

• ENST00000264690
• ENSP00000264690
• ENSG00000164344

Symbol

• KLK3
• PKK
• PPK
• KLK3
• PKKD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.94
protein domain	0.92
gene perturbation	0.67
disease	0.58
biological process	0.57

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Plasma Kallikrein

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Plasma Kallikrein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.69   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.69   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 862

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4