Protein Summary
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
- ENST00000264692
- ENSP00000264692
- ENSG00000088926
- ENST00000403665
- ENSP00000384957
- FXI
- PTA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological term | 0.84 | ||
molecular function | 0.73 | ||
gene perturbation | 0.63 | ||
disease | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.9 (req: < 5)
Gene RIFs: 147 (req: <= 3)
Antibodies: 431 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.9 (req: >= 5)
Gene RIFs: 147 (req: > 3)
Antibodies: 431 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 742
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (742)
Protein-Protein Interactions (96)
PRCC
Novelty: 0.00836323
p_int: 0.99918109
p_ni: 0.000805081
p_wrong: 0.000013829
Score: 0.26
Data Source: BioPlex,STRINGDB
APP
Novelty: 0.00008964
p_int: 0.954623545
p_ni: 0.045376455
Score: 0.423
Data Source: BioPlex,STRINGDB
CRELD2
Novelty: 0.09438775
p_int: 0.886266509
p_ni: 0.113733476
p_wrong: 1.5e-8
Score: 0.282
Data Source: BioPlex,STRINGDB
N4BP2L2
Novelty: 0.24527466
p_int: 0.756662129
p_ni: 0.239912216
p_wrong: 0.003425655
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (6)
Reactome (3)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Intrinsic Pathway of Fibrin Clot Formation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 7 | 1 | 1.2 | 99.6 | |||||
factor XI measurement | 2 | 3 | 3 | 99.3 | |||||
blood metabolite measurement | 2 | 3 | 3 | 97.1 | |||||
serum metabolite measurement | 2 | 2 | 3 | 95.6 | |||||
serum lipopolysaccharide activity | 1 | 1 | 1 | 94.7 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.2 | 99.6 | |||||
factor XI measurement | 3 | 99.3 | |||||
blood metabolite measurement | 3 | 97.1 | |||||
serum metabolite measurement | 3 | 95.6 | |||||
serum lipopolysaccharide activity | 1 | 94.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor XI | VGNC:2036 | 461643 | |||||
Macaque | coagulation factor XI | 702117 | ||||||
Mouse | MGI:99481 | 109821 | ||||||
Dog | coagulation factor XI | VGNC:40544 | 475623 | |||||
Horse | coagulation factor XI | VGNC:17753 | 100056603 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor XI | |||||
Macaque | coagulation factor XI | |||||
Mouse | ||||||
Dog | coagulation factor XI | |||||
Horse | coagulation factor XI | |||||
Publication Statistics
PubMed Score 751.90
PubMed score by year
PubTator Score 555.54
PubTator score by year
Related Publications
Text Mined References (194)
GeneRif Annotations (147)
Items per page:
0 of 0
PMID | Year | Title |
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