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Tbio
ANG
Angiogenin

Protein Summary
Description
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336811
  • ENSP00000336762
  • ENSG00000214274
  • ENST00000397990
  • ENSP00000381077

Symbol
  • RNASE5
  • ALS9
  • RAA1
  • HEL168
  • RNASE4
  • RNASE5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological process
0.98
virus perturbation
0.96
molecular function
0.93
biological term
0.89


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.55   (req: < 5)
Gene RIFs: 136   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.55   (req: >= 5)
Gene RIFs: 136   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiogenin
VGNC:10303
494026
Mouse
MGI:88022
11727
Rat
RGD:1359373
497229
Cow
angiogenin-1
783225
Cow
angiogenin, ribonuclease, RNase A family, 5
777597
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiogenin
Mouse
Rat
Cow
angiogenin-1
Cow
angiogenin, ribonuclease, RNase A family, 5
Protein Structure (46 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03950-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 46
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Protein-Protein Interactions (134)
1 – 10 of 134
RNH1
Tbio
Family: Enzyme
Novelty: 0.00307468
p_int: 0.907137542
p_ni: 0.000292125
p_wrong: 0.092570334
Score: 0.994
Data Source: BioPlex,STRINGDB
RNASE4
Tbio
Family: Enzyme
Novelty: 17
Score: 0.845
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.801
Data Source: STRINGDB
RNASE8
Tbio
Family: Enzyme
Novelty: 0.09513588
Score: 0.75
Data Source: STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00267471
Score: 0.748
Data Source: STRINGDB
ZNF699
Tbio
Family: TF
Novelty: 0.04644543
Score: 0.739
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.732
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.713
Data Source: STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.669
Data Source: STRINGDB
RNASET2
Tbio
Family: Enzyme
Novelty: 0.01939252
Score: 0.664
Data Source: STRINGDB
Publication Statistics
PubMed Score  717.55

PubMed score by year
PubTator Score  940.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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