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Tbio
MT-ATP8
ATP synthase protein 8

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361851
  • ENSP00000355265
  • ENSG00000228253

Symbol
  • ATP8
  • ATPASE8
  • MTATP8
  • ATPase8
  • MTATP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.87
biological process
0.74
cell line
0.7
molecular function
0.6
disease
0.5


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.35   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.35   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded ATP synthase membrane subunit 8
VGNC:11713
807862
Macaque
ATP synthase F0 subunit 8
2846623
Mouse
MGI:99926
17706
Rat
RGD:621240
26196
Dog
mitochondrially encoded ATP synthase membrane subunit 8
VGNC:53135
804487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded ATP synthase membrane subunit 8
Macaque
ATP synthase F0 subunit 8
Mouse
Rat
Dog
mitochondrially encoded ATP synthase membrane subunit 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P03928-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Metabolism of RNA
Mitochondrial biogenesis
Protein-Protein Interactions (99)
1 – 10 of 99
ATP5PF
Tbio
Family: Enzyme
Novelty: 0.00585408
p_int: 0.999969981
p_ni: 0.000030008
p_wrong: 1.2e-8
Score: 0.915
Data Source: BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty: 0.0563358
p_int: 0.998401508
p_ni: 0.001598453
p_wrong: 3.9e-8
Score: 0.665
Data Source: BioPlex,STRINGDB
TIMM8A
Tbio
Family: Enzyme
Novelty: 0.00954602
p_int: 0.99801293
p_ni: 0.001973855
p_wrong: 0.000013215
Data Source: BioPlex
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.996371988
p_ni: 0.003447198
p_wrong: 0.000180814
Data Source: BioPlex
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.07296539
p_int: 0.995492694
p_ni: 0.004501123
p_wrong: 0.000006183
Score: 0.974
Data Source: BioPlex,STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
p_int: 0.99532007
p_ni: 0.004663709
p_wrong: 0.000016221
Score: 0.977
Data Source: BioPlex,STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
p_int: 0.988948491
p_ni: 0.011037034
p_wrong: 0.000014475
Data Source: BioPlex
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.07345384
p_int: 0.985388179
p_ni: 0.014603111
p_wrong: 0.00000871
Score: 0.987
Data Source: BioPlex,STRINGDB
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
p_int: 0.98491739
p_ni: 0.015065989
p_wrong: 0.000016621
Score: 0.213
Data Source: BioPlex,STRINGDB
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.978117436
p_ni: 0.021873314
p_wrong: 0.00000925
Data Source: BioPlex
Publication Statistics
PubMed Score  391.35

PubMed score by year
PubTator Score  92.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer