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Tclin
MT-ND5
NADH-ubiquinone oxidoreductase chain 5

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361567
  • ENSP00000354813
  • ENSG00000198786

Symbol
  • MTND5
  • NADH5
  • ND5
  • MTND5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
phenotype
0.79
cellular component
0.77
protein domain
0.58
biological term
0.51


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.61   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.61   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
VGNC:11723
807860
Macaque
NADH dehydrogenase subunit 5
2846631
Mouse
MGI:102496
17721
Rat
RGD:620560
26202
Dog
NADH dehydrogenase subunit 5
804484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
Macaque
NADH dehydrogenase subunit 5
Mouse
Rat
Dog
NADH dehydrogenase subunit 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03915-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (148)
1 – 10 of 148
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999995391
p_ni: 0.000004522
p_wrong: 8.6e-8
Score: 0.985
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999992237
p_ni: 0.000007763
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999984131
p_ni: 0.000015868
Score: 0.995
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999937941
p_ni: 0.000062058
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999367197
p_ni: 0.000632803
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.998653355
p_ni: 0.001346364
p_wrong: 2.81e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
FNDC4
Tbio
Novelty: 0.31597146
p_int: 0.997595744
p_ni: 0.002404174
p_wrong: 8.2e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.996695045
p_ni: 0.003304955
Score: 0.994
Data Source: BioPlex,STRINGDB
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
p_int: 0.996626249
p_ni: 0.003373746
p_wrong: 5e-9
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.995110356
p_ni: 0.004889618
p_wrong: 2.7e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  455.61

PubMed score by year
PubTator Score  215.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer