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Tclin
MT-ND4
NADH-ubiquinone oxidoreductase chain 4

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361381
  • ENSP00000354961
  • ENSG00000198886

Symbol
  • MTND4
  • NADH4
  • ND4
  • MTND4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
cellular component
0.77
cell type or tissue
0.75
phenotype
0.75
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1252.67   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1252.67   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
VGNC:11721
807863
Macaque
NADH dehydrogenase subunit 4
2846630
Mouse
MGI:102498
17719
Rat
RGD:620559
26201
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
VGNC:53142
804483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
Macaque
NADH dehydrogenase subunit 4
Mouse
Rat
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03905-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (167)
1 – 10 of 167
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999989436
p_ni: 0.000010563
p_wrong: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999965792
p_ni: 0.000031942
p_wrong: 0.000002266
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999909889
p_ni: 0.000086405
p_wrong: 0.000003707
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999807941
p_ni: 0.00019186
p_wrong: 1.99e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999247041
p_ni: 0.00075262
p_wrong: 3.39e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.999074437
p_ni: 0.000925051
p_wrong: 5.12e-7
Data Source: BioPlex
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.998559166
p_ni: 0.001170566
p_wrong: 0.000270269
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.997941065
p_ni: 0.002058918
p_wrong: 1.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF4
Tclin
Family: Enzyme
Novelty: 0.10799507
p_int: 0.994295484
p_ni: 0.005533108
p_wrong: 0.000171407
Score: 0.935
Data Source: BioPlex,Reactome,STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.991893624
p_ni: 0.008105563
p_wrong: 8.13e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  1252.67

PubMed score by year
PubTator Score  284.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer