MT-ND4
NADH-ubiquinone oxidoreductase chain 4
Protein Classes
Protein Summary
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- ENST00000361381
- ENSP00000354961
- ENSG00000198886
- MTND4
- NADH4
- ND4
- MTND4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.99 | ||
cellular component | 0.77 | ||
cell type or tissue | 0.75 | ||
phenotype | 0.75 | ||
protein domain | 0.58 | ||
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1252.67 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 16 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1252.67 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 16 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (5)
1 – 5 of 5
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | VGNC:11721 | 807863 | |||||
Macaque | NADH dehydrogenase subunit 4 | 2846630 | ||||||
Mouse | MGI:102498 | 17719 | ||||||
Rat | RGD:620559 | 26201 | ||||||
Dog | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | VGNC:53142 | 804483 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | |||||
Macaque | NADH dehydrogenase subunit 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (18)
Reactome (10)
KEGG (5)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Metabolism of RNA | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Gene Ontology Terms (15)
Functions (2)
Components (3)
Processes (10)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (167)
1 – 10 of 167
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999989436
p_ni: 0.000010563
p_wrong: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
NDUFA8
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999965792
p_ni: 0.000031942
p_wrong: 0.000002266
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS6
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999909889
p_ni: 0.000086405
p_wrong: 0.000003707
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFB5
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999807941
p_ni: 0.00019186
p_wrong: 1.99e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999247041
p_ni: 0.00075262
p_wrong: 3.39e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
YIPF3
Novelty: 0.12021667
p_int: 0.999074437
p_ni: 0.000925051
p_wrong: 5.12e-7
Data Source: BioPlex
NDUFB11
Family: Enzyme
Novelty: 0.0401232
p_int: 0.998559166
p_ni: 0.001170566
p_wrong: 0.000270269
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFS3
Family: Enzyme
Novelty: 0.01968313
p_int: 0.997941065
p_ni: 0.002058918
p_wrong: 1.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF4
Family: Enzyme
Novelty: 0.10799507
p_int: 0.994295484
p_ni: 0.005533108
p_wrong: 0.000171407
Score: 0.935
Data Source: BioPlex,Reactome,STRINGDB
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.991893624
p_ni: 0.008105563
p_wrong: 8.13e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score 1252.67
PubMed score by year
PubTator Score 284.43
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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