Tclin MT-ND4 NADH-ubiquinone oxidoreductase chain 4

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Uniprot Accession IDs

• P03905
• Q6RL39
• Q6RQN9
• Q8HNR8

Gene Name

• MT-ND4

Ensembl ID

• ENST00000361381
• ENSP00000354961
• ENSG00000198886

Symbol

• MTND4
• NADH4
• ND4
• MTND4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.99
cellular component	0.77
cell type or tissue	0.75
phenotype	0.75
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh-ubiquinone Oxidoreductase Chain 4

Protein / Oxidoreductase / Dehydrogenase / Nadh-ubiquinone Oxidoreductase Chain 4

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh-ubiquinone Oxidoreductase Chain 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1911.36   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1911.36   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1