MT-ND4
NADH-ubiquinone oxidoreductase chain 4
Protein Summary
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- ENST00000361381
- ENSP00000354961
- ENSG00000198886
- MTND4
- NADH4
- ND4
- MTND4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.99 | ||
cellular component | 0.77 | ||
cell type or tissue | 0.75 | ||
phenotype | 0.75 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1350.99 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 16 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1350.99 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 16 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (1)
Active Ligands (5)
Protein-Protein Interactions (167)
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999989436
p_ni: 0.000010563
p_wrong: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
NDUFA8
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999965792
p_ni: 0.000031942
p_wrong: 0.000002266
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS6
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999909889
p_ni: 0.000086405
p_wrong: 0.000003707
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFB5
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999807941
p_ni: 0.00019186
p_wrong: 1.99e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999247041
p_ni: 0.00075262
p_wrong: 3.39e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
YIPF3
Novelty: 0.12021667
p_int: 0.999074437
p_ni: 0.000925051
p_wrong: 5.12e-7
Data Source: BioPlex
NDUFB11
Family: Enzyme
Novelty: 0.0401232
p_int: 0.998559166
p_ni: 0.001170566
p_wrong: 0.000270269
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFS3
Family: Enzyme
Novelty: 0.01968313
p_int: 0.997941065
p_ni: 0.002058918
p_wrong: 1.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF4
Family: Enzyme
Novelty: 0.10799507
p_int: 0.994295484
p_ni: 0.005533108
p_wrong: 0.000171407
Score: 0.935
Data Source: BioPlex,Reactome,STRINGDB
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.991893624
p_ni: 0.008105563
p_wrong: 8.13e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (10)
KEGG (5)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Metabolism of RNA | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (2)
Components (3)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | VGNC:11721 | 807863 | |||||
Macaque | NADH dehydrogenase subunit 4 | 2846630 | ||||||
Mouse | MGI:102498 | 17719 | ||||||
Rat | RGD:620559 | 26201 | ||||||
Dog | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | VGNC:53142 | 804483 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | |||||
Macaque | NADH dehydrogenase subunit 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | |||||
Publication Statistics
PubMed Score 1350.99
PubMed score by year
PubTator Score 284.43
PubTator score by year
Related Publications
Text Mined References (1)
GeneRif Annotations (38)
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