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Tclin
MT-ND4L
NADH-ubiquinone oxidoreductase chain 4L

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361335
  • ENSP00000354728
  • ENSG00000212907

Symbol
  • MTND4L
  • NADH4L
  • ND4L
  • MTND4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.61
disease
0.5
cellular component
0.49
pathway
0.48
phenotype
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.72   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.72   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
MT-ND1
Tclin
Family:  Enzyme
Novelty:  0.00090183
Score:  0.999
Data Source:  STRINGDB
MT-ND5
Tclin
Family:  Enzyme
Novelty:  0.00223164
Score:  0.999
Data Source:  STRINGDB
MT-ND2
Tclin
Family:  Enzyme
Novelty:  0.00069255
Score:  0.999
Data Source:  STRINGDB
MT-ND6
Tclin
Family:  Enzyme
Novelty:  0.00104547
Score:  0.999
Data Source:  STRINGDB
MT-ND4
Tclin
Family:  Enzyme
Novelty:  0.00079935
Score:  0.999
Data Source:  STRINGDB
MT-ND3
Tclin
Family:  Enzyme
Novelty:  0.00161513
Score:  0.999
Data Source:  STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
Score:  0.998
Data Source:  STRINGDB
MT-ATP6
Tbio
Family:  Enzyme
Novelty:  0.00104191
Score:  0.993
Data Source:  STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
Score:  0.991
Data Source:  STRINGDB
NDUFS2
Tclin
Family:  Enzyme
Novelty:  0.02347576
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Reactome
tRNA processing
Reactome
tRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA processing
rRNA processing in the mitochondrion
tRNA processing
tRNA processing in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L
VGNC:11722
807868
Macaque
NADH dehydrogenase subunit 4L
2846621
Mouse
MGI:102497
17720
Rat
RGD:620494
26200
Dog
NADH dehydrogenase subunit 4L
804482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L
Macaque
NADH dehydrogenase subunit 4L
Mouse
Rat
Dog
NADH dehydrogenase subunit 4L
Publication Statistics
PubMed Score 227.72
PubMed score by year
PubTator Score 26.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title