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Tclin
MT-ND3
NADH-ubiquinone oxidoreductase chain 3

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361227
  • ENSP00000355206
  • ENSG00000198840

Symbol
  • MTND3
  • NADH3
  • ND3
  • MTND3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.77
phenotype
0.64
small molecule perturbation
0.63
protein complex
0.57
microRNA
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.55   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.55   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
VGNC:11720
807870
Macaque
NADH dehydrogenase subunit 3
2846622
Mouse
MGI:102499
17718
Rat
RGD:620557
26199
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
VGNC:53141
804481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
Macaque
NADH dehydrogenase subunit 3
Mouse
Rat
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03897-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (144)
1 – 10 of 144
NDUFS2
Tclin
Family: Enzyme
Novelty: 0.02347576
Score: 0.999
Data Source: STRINGDB
NDUFA6
Tclin
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFV2
Tclin
Family: Enzyme
Novelty: 0.02240263
Score: 0.999
Data Source: STRINGDB
MT-ND2
Tclin
Family: Enzyme
Novelty: 0.00069255
Score: 0.999
Data Source: Reactome,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
Score: 0.999
Data Source: STRINGDB
MT-ND6
Tclin
Family: Enzyme
Novelty: 0.00104547
Score: 0.999
Data Source: Reactome,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
Score: 0.999
Data Source: Reactome,STRINGDB
NDUFV1
Tclin
Family: Enzyme
Novelty: 0.01929835
Score: 0.999
Data Source: STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
Score: 0.999
Data Source: Reactome,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  616.55

PubMed score by year
PubTator Score  208.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer