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Tclin
MT-ND2
NADH-ubiquinone oxidoreductase chain 2

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361453
  • ENSP00000355046
  • ENSG00000198763

Symbol
  • MTND2
  • NADH2
  • ND2
  • MTND2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
small molecule perturbation
1
cellular component
0.77
protein complex
0.57
disease
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1448.75   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1448.75   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
VGNC:11719
807865
Macaque
NADH dehydrogenase subunit 2
2846626
Mouse
MGI:102500
17717
Rat
RGD:620556
26194
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
VGNC:53140
804477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
Macaque
NADH dehydrogenase subunit 2
Mouse
Rat
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03891-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Protein-Protein Interactions (151)
1 – 10 of 151
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999937901
p_ni: 0.000060962
p_wrong: 0.000001136
Score: 0.983
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.995969677
p_ni: 0.004030083
p_wrong: 2.4e-7
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.985786384
p_ni: 0.010132784
p_wrong: 0.004080832
Score: 0.999
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.975800635
p_ni: 0.019921607
p_wrong: 0.004277757
Data Source: BioPlex
FNDC4
Tbio
Novelty: 0.31597146
p_int: 0.97354103
p_ni: 0.020669166
p_wrong: 0.005789804
Score: 0.219
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.95661903
p_ni: 0.030284649
p_wrong: 0.01309632
Score: 0.995
Data Source: BioPlex,STRINGDB
MT-ND1
Tclin
Family: Enzyme
Novelty: 0.00090183
Score: 0.999
Data Source: Reactome,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
Score: 0.999
Data Source: Reactome,STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
Score: 0.999
Data Source: Reactome,STRINGDB
NDUFA6
Tclin
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  1448.75

PubMed score by year
PubTator Score  285.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer