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Tclin
ESR1
Estrogen receptor

Protein Summary
Description
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B resp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206249
  • ENSP00000206249
  • ENSG00000091831
  • ENST00000338799
  • ENSP00000342630
  • ENST00000440973
  • ENSP00000405330
  • ENST00000443427
  • ENSP00000387500

Symbol
  • ESR
  • NR3A1
  • ER
  • ESR
  • Era
  • ESRA
  • ESTRR
  • NR3A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
hub protein
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15568.99   (req: < 5)
Gene RIFs: 2353   (req: <= 3)
Antibodies: 3731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15568.99   (req: >= 5)
Gene RIFs: 2353   (req: > 3)
Antibodies: 3731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 932
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
5
5
6
98.7
self reported educational attainment
3
3
3
98.5
heel bone mineral density
3
9
19
98.5
birth weight
5
3
5
98.1
body height
3
4
4
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
6
98.7
self reported educational attainment
3
98.5
heel bone mineral density
19
98.5
birth weight
5
98.1
body height
4
93.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor 1
VGNC:2781
463079
Macaque
estrogen receptor 1
613025
Mouse
MGI:1352467
13982
Rat
RGD:2581
24890
Dog
estrogen receptor 1
VGNC:40476
403640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen receptor 1
Macaque
estrogen receptor 1
Mouse
Rat
Dog
estrogen receptor 1
Protein Structure (266 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03372-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 266
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ESR-mediated signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Deubiquitination
Disease
Diseases of signal transduction
ESR-mediated signaling
Gene Ontology Terms (84)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Protein-Protein Interactions (861)
1 – 10 of 861
PPP1R14C
Tbio
Family: Enzyme
Novelty: 0.04635786
p_int: 0.999521064
p_ni: 0.000469328
p_wrong: 0.000009608
Score: 0.379
Data Source: BioPlex,STRINGDB
GBP1
Tbio
Novelty: 0.00634662
p_int: 0.999302822
p_ni: 0.000697103
p_wrong: 7.5e-8
Score: 0.284
Data Source: BioPlex,STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
p_int: 0.997760062
p_ni: 0.002239523
p_wrong: 4.15e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
SIGLEC10
Tbio
Novelty: 0.02858542
p_int: 0.993513533
p_ni: 0.006486467
Score: 0.345
Data Source: BioPlex,STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00178141
p_int: 0.929202421
p_ni: 0.042326228
p_wrong: 0.028471351
Score: 0.555
Data Source: BioPlex,STRINGDB
CNDP1
Tbio
Family: Enzyme
Novelty: 0.0102642
p_int: 0.901555575
p_ni: 0.098441636
p_wrong: 0.00000279
Score: 0.194
Data Source: BioPlex,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.997
Data Source: Reactome,STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.995
Data Source: STRINGDB
PELP1
Tbio
Novelty: 0.00817675
Score: 0.995
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  15568.99

PubMed score by year
PubTator Score  12162.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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