You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ESR1
Estrogen receptor

Protein Summary
Description
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B resp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206249
  • ENSP00000206249
  • ENSG00000091831
  • ENST00000338799
  • ENSP00000342630
  • ENST00000440973
  • ENSP00000405330
  • ENST00000443427
  • ENSP00000387500

Symbol
  • ESR
  • NR3A1
  • ER
  • ESR
  • Era
  • ESRA
  • ESTRR
  • NR3A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31936.78   (req: < 5)
Gene RIFs: 2353   (req: <= 3)
Antibodies: 3731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31936.78   (req: >= 5)
Gene RIFs: 2353   (req: > 3)
Antibodies: 3731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1606
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 27