Protein Summary
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10086.95 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 906 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10086.95 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 906 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 94.7 | |||||
HbA1c measurement | 4 | 4 | 4 | 90.9 | |||||
mean corpuscular volume | 2 | 2 | 2 | 90.1 | |||||
serum urea measurement | 1 | 2 | 2 | 75.4 | |||||
red blood cell distribution width | 1 | 2 | 2 | 74.4 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 94.7 | |||||
HbA1c measurement | 4 | 90.9 | |||||
mean corpuscular volume | 2 | 90.1 | |||||
serum urea measurement | 2 | 75.4 | |||||
red blood cell distribution width | 2 | 74.4 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bone gamma-carboxyglutamate protein | VGNC:8149 | 100190891 | |||||
Macaque | bone gamma-carboxyglutamate protein | 718296 | ||||||
Mouse | MGI:88157 | 12097 | ||||||
Mouse | MGI:88155 | 12095 | ||||||
Rat | RGD:2206 | 25295 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bone gamma-carboxyglutamate protein | |||||
Macaque | bone gamma-carboxyglutamate protein | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (46)
Reactome (13)
KEGG (1)
PathwayCommons (5)
WikiPathways (27)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Gamma-carboxylation of protein precursors | ||||
Reactome | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Gamma-carboxylation of protein precursors | ||||
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (40)
Functions (4)
Components (9)
Processes (27)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Protein-Protein Interactions (208)
1 – 10 of 208
P3H2
Family: Enzyme
Novelty: 0.04237396
p_int: 0.999998788
p_ni: 0.000001212
Data Source: BioPlex
SEH1L
Novelty: 0.03666501
p_int: 0.99912467
p_ni: 0.00087533
Data Source: BioPlex
POC1A
Novelty: 0.03897985
p_int: 0.949737661
p_ni: 0.006387716
p_wrong: 0.043874623
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.924619029
p_ni: 0.075380971
Data Source: BioPlex
NDUFAF7
Family: Enzyme
Novelty: 0.24691414
p_int: 0.817982042
p_ni: 0.181750491
p_wrong: 0.000267467
Data Source: BioPlex
GRN
Novelty: 0.00096395
p_int: 0.775823501
p_ni: 0.158687199
p_wrong: 0.0654893
Data Source: BioPlex
GGCX
Family: Enzyme
Novelty: 0.00819484
Score: 0.975
Data Source: Reactome,STRINGDB
RUNX2
Family: TF
Novelty: 0.00028804
Score: 0.971
Data Source: STRINGDB
PTH
Novelty: 0.00003263
Score: 0.957
Data Source: STRINGDB
SP7
Family: TF
Novelty: 0.00102606
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score 10086.95
PubMed score by year
PubTator Score 6385.92
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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GWAS Trait
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