Tbio BGLAP Osteocalcin

Protein Summary

Description

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

Uniprot Accession IDs

• P02818
• Q5TCK6

Gene Name

• BGLAP

Ensembl ID

• ENST00000368272
• ENSP00000357255
• ENSG00000242252

Symbol

• OC
• BGP
• OCN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.91
disease	0.83
chemical	0.79
phenotype	0.76
biological process	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10850.71   (req: < 5)

Gene RIFs: 242   (req: <= 3)

Antibodies: 906   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10850.71   (req: >= 5)

Gene RIFs: 242   (req: > 3)

Antibodies: 906   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0