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Tbio
BGLAP
Osteocalcin

Protein Summary
Description
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368272
  • ENSP00000357255
  • ENSG00000242252

Symbol
  • OC
  • BGP
  • OCN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
disease
0.83
chemical
0.79
phenotype
0.76
biological process
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10086.95   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 906   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10086.95   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 906   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
94.7
HbA1c measurement
4
4
4
90.9
mean corpuscular volume
2
2
2
90.1
serum urea measurement
1
2
2
75.4
red blood cell distribution width
1
2
2
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
94.7
HbA1c measurement
4
90.9
mean corpuscular volume
2
90.1
serum urea measurement
2
75.4
red blood cell distribution width
2
74.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone gamma-carboxyglutamate protein
VGNC:8149
100190891
Macaque
bone gamma-carboxyglutamate protein
718296
Mouse
MGI:88157
12097
Mouse
MGI:88155
12095
Rat
RGD:2206
25295
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone gamma-carboxyglutamate protein
Macaque
bone gamma-carboxyglutamate protein
Mouse
Mouse
Rat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P02818-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (46)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Reactome
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (40)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (208)
1 – 10 of 208
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.999998788
p_ni:  0.000001212
Data Source:  BioPlex
SEH1L
Tbio
Novelty:  0.03666501
p_int:  0.99912467
p_ni:  0.00087533
Data Source:  BioPlex
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.949737661
p_ni:  0.006387716
p_wrong:  0.043874623
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.924619029
p_ni:  0.075380971
Data Source:  BioPlex
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.817982042
p_ni:  0.181750491
p_wrong:  0.000267467
Data Source:  BioPlex
GRN
Tbio
Novelty:  0.00096395
p_int:  0.775823501
p_ni:  0.158687199
p_wrong:  0.0654893
Data Source:  BioPlex
GGCX
Tclin
Family:  Enzyme
Novelty:  0.00819484
Score:  0.975
Data Source:  Reactome,STRINGDB
RUNX2
Tbio
Family:  TF
Novelty:  0.00028804
Score:  0.971
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.957
Data Source:  STRINGDB
SP7
Tbio
Family:  TF
Novelty:  0.00102606
Score:  0.95
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10086.95

PubMed score by year
PubTator Score  6385.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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