Protein Summary
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10086.95 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 906 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10086.95 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 906 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (208)
P3H2
Family: Enzyme
Novelty: 0.04237396
p_int: 0.999998788
p_ni: 0.000001212
Data Source: BioPlex
POC1A
Novelty: 0.03897985
p_int: 0.949737661
p_ni: 0.006387716
p_wrong: 0.043874623
Data Source: BioPlex
NDUFAF7
Family: Enzyme
Novelty: 0.24691414
p_int: 0.817982042
p_ni: 0.181750491
p_wrong: 0.000267467
Data Source: BioPlex
GRN
Novelty: 0.00096395
p_int: 0.775823501
p_ni: 0.158687199
p_wrong: 0.0654893
Data Source: BioPlex
Nearest Tclin Targets
Pathways (46)
Reactome (13)
KEGG (1)
PathwayCommons (5)
WikiPathways (27)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Gamma-carboxylation of protein precursors | ||||
Reactome | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Gamma-carboxylation of protein precursors | ||||
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (4)
Components (9)
Processes (27)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 94.7 | |||||
HbA1c measurement | 4 | 4 | 4 | 90.9 | |||||
mean corpuscular volume | 2 | 2 | 2 | 90.1 | |||||
serum urea measurement | 1 | 2 | 2 | 75.4 | |||||
red blood cell distribution width | 1 | 2 | 2 | 74.4 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 94.7 | |||||
HbA1c measurement | 4 | 90.9 | |||||
mean corpuscular volume | 2 | 90.1 | |||||
serum urea measurement | 2 | 75.4 | |||||
red blood cell distribution width | 2 | 74.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bone gamma-carboxyglutamate protein | VGNC:8149 | 100190891 | |||||
Macaque | bone gamma-carboxyglutamate protein | 718296 | ||||||
Mouse | MGI:88157 | 12097 | ||||||
Mouse | MGI:88155 | 12095 | ||||||
Rat | RGD:2206 | 25295 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bone gamma-carboxyglutamate protein | |||||
Macaque | bone gamma-carboxyglutamate protein | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 10086.95
PubMed score by year
PubTator Score 6385.92
PubTator score by year
Related Publications
Text Mined References (231)
GeneRif Annotations (193)
Items per page:
0 of 0
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