Tbio MT2A Metallothionein-2

Protein Summary

Description

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]

Uniprot Accession IDs

• P02795
• Q14823
• Q2HXR9
• Q53XT9
• MT-2

Gene Name

• MT2A

Ensembl ID

• ENST00000245185
• ENSP00000245185
• ENSG00000125148

Symbol

• CES1
• MT2
• MT2
• MT-2
• MT-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.84
small molecule perturbation	0.74
protein domain	0.73
disease	0.69

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.76   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.76   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Dog	metallothionein 1H		403768
Horse	metallothionein-1A-like		100630858
Cow	metallothionein 2A		404070
Pig	metallothionein-2A		396827
Pig	metallothionein 1A		397417

Species	Name	OMA	EggNOG	Inparanoid
Dog	metallothionein 1H
Horse	metallothionein-1A-like
Cow	metallothionein 2A
Pig	metallothionein-2A
Pig	metallothionein 1A

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02795-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (19)

Reactome (7)

KEGG (1)

PathwayCommons (1)

WikiPathways (10)

Cellular responses to external stimuli (R-HSA-8953897)

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Find Similar Targets

Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531
Reactome	Interferon gamma signaling	172 targets	R-HSA-877300

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531
Interferon gamma signaling	172 targets	R-HSA-877300

Gene Ontology Terms (19)

Functions (3)

Components (4)

Processes (12)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
drug binding	Inferred from Direct Assay (IDA)	UniProtKB
zinc ion binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (243)

Explore Interacting Targets

1 – 10 of 243

• See Interactions on String-DB

B2M

Tbio

Novelty: 0.00011248

Score: 0.937

Data Source: STRINGDB

GBP1

Tbio

Novelty: 0.00634662

Score: 0.918

Data Source: STRINGDB

IRF1

Tbio

Family: TF

Novelty: 0.00099983

Score: 0.917

Data Source: STRINGDB

OASL

Tbio

Family: Enzyme

Novelty: 0.01502223

Score: 0.916

Data Source: STRINGDB

CD44

Tbio

Novelty: 0.00011321

Score: 0.914

Data Source: STRINGDB

OAS2

Tbio

Family: Enzyme

Novelty: 0.01673393

Score: 0.911

Data Source: STRINGDB

ICAM1

Tchem

Novelty: 0.00009746

Score: 0.91

Data Source: STRINGDB

HLA-A

Tbio

Novelty: 0.00270731

Score: 0.908

Data Source: STRINGDB

HLA-A

Tbio

Novelty: 0.00270731

Score: 0.908

Data Source: STRINGDB

HLA-A

Tbio

Novelty: 0.00270731

Score: 0.908

Data Source: STRINGDB

Publication Statistics

PubMed Score  657.76

PubMed score by year

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PubTator Score  768.04

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Metal-binding
Metal-thiolate cluster
Phosphoprotein
Polymorphism
Reference proteome
Zinc