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Tbio
MT2A
Metallothionein-2

Protein Summary
Description
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245185
  • ENSP00000245185
  • ENSG00000125148

Symbol
  • CES1
  • MT2
  • MT2
  • MT-2
  • MT-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.84
small molecule perturbation
0.74
protein domain
0.73
disease
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.76   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.76   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
metallothionein 1H
403768
Horse
metallothionein-1A-like
100630858
Cow
metallothionein 2A
404070
Pig
metallothionein-2A
396827
Pig
metallothionein 1A
397417
Species
Name
OMA
EggNOG
Inparanoid
Dog
metallothionein 1H
Horse
metallothionein-1A-like
Cow
metallothionein 2A
Pig
metallothionein-2A
Pig
metallothionein 1A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02795-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (243)
1 – 10 of 243
B2M
Tbio
Novelty: 0.00011248
Score: 0.937
Data Source: STRINGDB
GBP1
Tbio
Novelty: 0.00634662
Score: 0.918
Data Source: STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00099983
Score: 0.917
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.916
Data Source: STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.914
Data Source: STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.01673393
Score: 0.911
Data Source: STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.91
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.908
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.908
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  657.76

PubMed score by year
PubTator Score  768.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer