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Tbio
FTL
Ferritin light chain

Protein Classes
Protein Summary
Description
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
kinase perturbation
0.97
transcription factor binding site profile
0.96
transcription factor perturbation
0.94
disease perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.73   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 929   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.73   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 929   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
95.1
reticulocyte measurement
3
4
5
95
reticulocyte count
6
3
11
92.3
testosterone measurement
6
6
6
88
eosinophil count
3
1
3
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
95.1
reticulocyte measurement
5
95
reticulocyte count
11
92.3
testosterone measurement
6
88
eosinophil count
3
70.9
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ferritin light chain
718964
Mouse
MGI:95589
14325
Cow
ferritin light chain
783993
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ferritin light chain
Mouse
Cow
ferritin light chain
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02792-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Golgi Associated Vesicle Biogenesis
Immune System
Innate Immune System
Iron uptake and transport
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (194)
1 – 10 of 194
FTH1
Tbio
Novelty:  0.000863
p_int:  0.9999866
p_ni:  0.0000134
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.991964553
p_ni:  0.008035447
Score:  0.204
Data Source:  BioPlex,STRINGDB
NKAP
Tbio
Novelty:  0.04982584
p_int:  0.988833008
p_ni:  0.011166992
Score:  0.514
Data Source:  BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
p_int:  0.986202193
p_ni:  0.013797807
Score:  0.392
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.985755216
p_ni:  0.014244784
Data Source:  BioPlex
NCOA4
Tbio
Novelty:  0.00487453
p_int:  0.981822336
p_ni:  0.01817764
p_wrong:  2.5e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
ZCCHC17
Tbio
Novelty:  0.06999007
p_int:  0.946900267
p_ni:  0.053099733
Score:  0.159
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.907094069
p_ni:  0.09290593
p_wrong:  1e-9
Data Source:  BioPlex
ZNF558
Tdark
Family:  TF
Novelty:  0.821338
p_int:  0.822749059
p_ni:  0.177246919
p_wrong:  0.000004022
Score:  0.195
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.810054655
p_ni:  0.189915219
p_wrong:  0.000030125
Score:  0.436
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  439.73

PubMed score by year
PubTator Score  147.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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