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Tbio
LTF
Lactotransferrin

Protein Summary
Description
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting a ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
biological term
0.97
molecular function
0.96
small molecule perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 856.76   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 1219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 856.76   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 1219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999997774
p_ni:  0.000002226
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999965689
p_ni:  0.000034311
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999801173
p_ni:  0.000198827
Score:  0.2
Data Source:  BioPlex,STRINGDB
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999658439
p_ni:  0.000341561
Data Source:  BioPlex
CCDC148
Tdark
Novelty:  2.81805259
p_int:  0.999161952
p_ni:  0.000838047
Score:  0.196
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.998384769
p_ni:  0.001615231
Data Source:  BioPlex
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
p_int:  0.994555369
p_ni:  0.005444631
Score:  0.17
Data Source:  BioPlex,STRINGDB
FN3KRP
Tbio
Family:  Kinase
Novelty:  0.10259418
p_int:  0.97039602
p_ni:  0.02960398
Score:  0.235
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.968423716
p_ni:  0.031576279
p_wrong:  5e-9
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.960652736
p_ni:  0.039347264
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (84)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Antimicrobial peptides
Reactome
Disease
Reactome
Immune System
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Antimicrobial peptides
Disease
Immune System
Infectious disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (58)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
4
4
97.2
macrophage inflammatory protein 1b measurement
1
3
3
96
monocyte percentage of leukocytes
2
4
4
94.3
Oral ulcer
1
2
0
1.1
93.2
CCL2 measurement
2
3
3
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
97.2
macrophage inflammatory protein 1b measurement
3
96
monocyte percentage of leukocytes
4
94.3
Oral ulcer
0
1.1
93.2
CCL2 measurement
3
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactotransferrin
VGNC:1866
460325
Macaque
lactotransferrin
713115
Mouse
MGI:96837
17002
Rat
RGD:1305445
301034
Dog
lactotransferrin
VGNC:42861
484787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactotransferrin
Macaque
lactotransferrin
Mouse
Rat
Dog
lactotransferrin
Publication Statistics
PubMed Score 856.76
PubMed score by year
PubTator Score 214.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title