Tclin TFRC Transferrin receptor protein 1

Protein Summary

Description

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P02786
• D3DXB0
• Q1HE24
• Q59G55
• Q9UCN0
• Q9UCU5
• Q9UDF9
• Q9UK21
• TR

Gene Name

• TFRC

Ensembl ID

• ENST00000360110
• ENSP00000353224
• ENSG00000072274
• ENST00000392396
• ENSP00000376197

Symbol

• T9
• TR
• TFR
• p90
• CD71
• TFR1
• TRFR
• IMD46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	1
kinase perturbation	0.99
transcription factor binding site profile	0.96
chemical	0.91

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Transferrin Receptor Protein 1

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Transferrin Receptor Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4396.49   (req: < 5)

Gene RIFs: 252   (req: <= 3)

Antibodies: 2674   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4396.49   (req: >= 5)

Gene RIFs: 252   (req: > 3)

Antibodies: 2674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1