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Tbio
TFRC
Transferrin receptor protein 1

Protein Summary
Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360110
  • ENSP00000353224
  • ENSG00000072274
  • ENST00000392396
  • ENSP00000376197

Symbol
  • T9
  • TR
  • TFR
  • p90
  • CD71
  • TFR1
  • TRFR
  • IMD46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.96
chemical
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3716.44   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 2674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3716.44   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 2674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
8
9
94.8
mean corpuscular volume
4
4
5
93.1
mean corpuscular hemoglobin concentration
3
3
3
92.1
3
3
2
1.1
88.2
mean corpuscular hemoglobin
2
2
2
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
9
94.8
mean corpuscular volume
5
93.1
mean corpuscular hemoglobin concentration
3
92.1
2
1.1
88.2
mean corpuscular hemoglobin
2
85.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transferrin receptor
VGNC:2602
460956
Macaque
transferrin receptor
711568
Mouse
MGI:98822
22042
Rat
RGD:70488
64678
Dog
transferrin receptor
VGNC:47305
403703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transferrin receptor
Macaque
transferrin receptor
Mouse
Rat
Dog
transferrin receptor
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Iron uptake and transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Iron uptake and transport
Membrane Trafficking
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (467)
1 – 10 of 467
PIK3IP1
Tbio
Family: Enzyme
Novelty: 0.07364653
p_int: 0.947729309
p_ni: 0.052270691
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00042077
Score: 0.998
Data Source: Reactome,STRINGDB
TF
Tbio
Novelty: 0.00231826
Score: 0.994
Data Source: Reactome,STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.988
Data Source: STRINGDB
FTH1
Tbio
Novelty: 0.000863
Score: 0.978
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.971
Data Source: STRINGDB
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.97
Data Source: STRINGDB
TGOLN2
Tbio
Novelty: 0.005107
Score: 0.969
Data Source: STRINGDB
FTL
Tbio
Novelty: 0.00235168
Score: 0.966
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  3716.44

PubMed score by year
PubTator Score  1504.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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