Tbio CXCL10 C-X-C motif chemokine 10

Protein Summary

Description

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P02778
• Q96QJ5

Gene Name

• CXCL10

Ensembl ID

• ENST00000306602
• ENSP00000305651
• ENSG00000169245

Symbol

• INP10
• SCYB10
• C7
• IFI10
• INP10
• IP-10
• crg-2
• mob-1
• SCYB10
• gIP-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
PubMedID	1
virus perturbation	1
chemical	0.95

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-x-c Motif Chemokine 10

DTO Classes

Protein / Signaling / Chemokine / C-x-c Motif Chemokine 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3303.89   (req: < 5)

Gene RIFs: 685   (req: <= 3)

Antibodies: 777   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3303.89   (req: >= 5)

Gene RIFs: 685   (req: > 3)

Antibodies: 777   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0