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Tchem
CXCL10
C-X-C motif chemokine 10

Protein Summary
Description
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306602
  • ENSP00000305651
  • ENSG00000169245

Symbol
  • INP10
  • SCYB10
  • C7
  • IFI10
  • INP10
  • IP-10
  • crg-2
  • mob-1
  • SCYB10
  • gIP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
virus perturbation
1
chemical
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2649.37   (req: < 5)
Gene RIFs: 518   (req: <= 3)
Antibodies: 777   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2649.37   (req: >= 5)
Gene RIFs: 518   (req: > 3)
Antibodies: 777   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 181
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
1
1
0
1.8
88.4
protein measurement
1
1
1
58.3
fetal genotype effect measurement
1
1
1
58.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.8
88.4
protein measurement
1
58.3
fetal genotype effect measurement
1
58.3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (62)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (45)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (532)
1 – 10 of 532
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.997
Data Source: Reactome,STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.995
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.991
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.991
Data Source: STRINGDB
CXCL11
Tbio
Novelty: 0.00077765
Score: 0.988
Data Source: STRINGDB
CCL11
Tbio
Novelty: 0.00086805
Score: 0.988
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.988
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.987
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.987
Data Source: STRINGDB
CXCL2
Tbio
Novelty: 0.00201175
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  2649.37

PubMed score by year
PubTator Score  1394.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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