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Tbio
PF4
Platelet factor 4

Protein Summary
Description
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296029
  • ENSP00000296029
  • ENSG00000163737

Symbol
  • CXCL4
  • SCYB4
  • PF-4
  • CXCL4
  • SCYB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.93
gene perturbation
0.84
molecular function
0.6
disease
0.58


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2740.79   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2740.79   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
1
2
52.6
protein measurement
1
1
1
33.9
blood metabolite measurement
1
1
1
33.9
amino acid measurement
1
1
1
33.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
52.6
protein measurement
1
33.9
blood metabolite measurement
1
33.9
amino acid measurement
1
33.9
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet factor 4
VGNC:658
740477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet factor 4
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02776-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Gene Ontology Terms (38)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (376)
1 – 10 of 376
BLZF1
Tbio
Novelty: 0.04344183
p_int: 0.999975835
p_ni: 0.000024165
Data Source: BioPlex
MOCS1
Tbio
Novelty: 0.02785369
p_int: 0.997816173
p_ni: 0.002183779
p_wrong: 4.8e-8
Data Source: BioPlex
CCL5
Tchem
Novelty: 0.00032607
Score: 0.99
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.984
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.983
Data Source: STRINGDB
PPBP
Tbio
Novelty: 0.00048307
Score: 0.98
Data Source: STRINGDB
CXCL11
Tbio
Novelty: 0.00077765
Score: 0.979
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.978
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.977
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  2740.79

PubMed score by year
PubTator Score  1202.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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