Tbio PF4 Platelet factor 4

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Platelet Factor 4

Protein Summary

Description

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P02776
• Q53X61
• Q9UC64
• Q9UC65
• PF-4

Gene Name

• PF4

Ensembl ID

• ENST00000296029
• ENSP00000296029
• ENSG00000163737

Symbol

• CXCL4
• SCYB4
• PF-4
• CXCL4
• SCYB4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
biological term	0.93
gene perturbation	0.84
molecular function	0.6
disease	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2225.27   (req: < 5)

Gene RIFs: 134   (req: <= 3)

Antibodies: 455   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2225.27   (req: >= 5)

Gene RIFs: 134   (req: > 3)

Antibodies: 455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (10)

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (27)

Reactome (20)

KEGG (3)

PathwayCommons (2)

WikiPathways (2)

Cell surface interactions at the vascular wall (R-HSA-202733)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877

Gene Ontology Terms (38)

Functions (3)

Components (7)

Processes (28)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
CXCR3 chemokine receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
heparin binding	Inferred from Direct Assay (IDA)	UniProtKB
chemokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (376)

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1 – 10 of 376

• See Interactions on String-DB

BLZF1

Tbio

Novelty: 0.07416445

p_int: 0.999975835

p_ni: 0.000024165

Data Source: BioPlex

MOCS1

Tbio

Novelty: 0.04431171

p_int: 0.997816173

p_ni: 0.002183779

p_wrong: 4.8e-8

Data Source: BioPlex

CCL5

Tchem

Novelty: 0.00039604

Score: 0.99

Data Source: STRINGDB

CXCR3

Tchem

Family: GPCR

Novelty: 0.00129022

Score: 0.984

Data Source: STRINGDB

CXCL9

Tbio

Novelty: 0.00107245

Score: 0.983

Data Source: STRINGDB

PPBP

Tbio

Novelty: 0.00058824

Score: 0.98

Data Source: STRINGDB

CXCL11

Tbio

Novelty: 0.00172274

Score: 0.979

Data Source: STRINGDB

CXCL10

Tchem

Novelty: 0.00051044

Score: 0.978

Data Source: STRINGDB

CCL20

Tbio

Novelty: 0.00082571

Score: 0.977

Data Source: STRINGDB

CXCL12

Tbio

Novelty: 0.00031121

Score: 0.975

Data Source: STRINGDB

Publication Statistics

PubMed Score  2225.27

PubMed score by year

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PubTator Score  1202.68

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Heparin-binding
Phosphoprotein
Reference proteome
Secreted

GWAS Trait Find Similar Targets

amino acid measurement
blood metabolite measurement
CXCL5 measurement
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protein measurement
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MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype