Protein Classes
Protein Summary
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]
- ENST00000296029
- ENSP00000296029
- ENSG00000163737
- CXCL4
- SCYB4
- PF-4
- CXCL4
- SCYB4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
biological term | 0.93 | ||
gene perturbation | 0.84 | ||
molecular function | 0.6 | ||
disease | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2225.27 (req: < 5)
Gene RIFs: 134 (req: <= 3)
Antibodies: 455 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2225.27 (req: >= 5)
Gene RIFs: 134 (req: > 3)
Antibodies: 455 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (27)
Reactome (20)
KEGG (3)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 20
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Common Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Gene Ontology Terms (38)
Functions (3)
Components (7)
Processes (28)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (376)
1 – 10 of 376
BLZF1
Novelty: 0.07416445
p_int: 0.999975835
p_ni: 0.000024165
Data Source: BioPlex
MOCS1
Novelty: 0.04431171
p_int: 0.997816173
p_ni: 0.002183779
p_wrong: 4.8e-8
Data Source: BioPlex
CCL5
Novelty: 0.00039604
Score: 0.99
Data Source: STRINGDB
CXCR3
Family: GPCR
Novelty: 0.00129022
Score: 0.984
Data Source: STRINGDB
CXCL9
Novelty: 0.00107245
Score: 0.983
Data Source: STRINGDB
PPBP
Novelty: 0.00058824
Score: 0.98
Data Source: STRINGDB
CXCL11
Novelty: 0.00172274
Score: 0.979
Data Source: STRINGDB
CXCL10
Novelty: 0.00051044
Score: 0.978
Data Source: STRINGDB
CCL20
Novelty: 0.00082571
Score: 0.977
Data Source: STRINGDB
CXCL12
Novelty: 0.00031121
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score 2225.27
PubMed score by year
PubTator Score 1202.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait