Tbio PPBP Platelet basic protein

Protein Summary

Description

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P02775
• B2R5F3
• Q6IBJ8
• PBP

Gene Name

• PPBP

Ensembl ID

• ENST00000296028
• ENSP00000296028
• ENSG00000163736

Symbol

• CTAP3
• CXCL7
• SCYB7
• TGB1
• THBGB1
• PBP
• TC1
• TC2
• TGB
• LDGF
• MDGF
• TGB1
• B-TG1
• CTAP3
• CXCL7
• NAP-2
• SCYB7
• THBGB
• LA-PF4
• THBGB1
• Beta-TG
• CTAPIII
• CTAP-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
biological process	0.69
disease	0.68
gene perturbation	0.67
PubMedID	0.67

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Platelet Basic Protein

DTO Classes

Protein / Signaling / Chemokine / Platelet Basic Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2239.86   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 594   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2239.86   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0