Protein Summary
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
- ENST00000273951
- ENSP00000273951
- ENSG00000145321
- ENST00000504199
- ENSP00000421725
- DBP
- VDB
- GRD3
- VDBG
- VDBP
- GcMAF
- DBP/GC
- Gc-MAF
- DBP-maf
- HEL-S-51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.88 | ||
protein domain | 0.85 | ||
cellular component | 0.67 | ||
disease | 0.65 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1698.53 (req: < 5)
Gene RIFs: 213 (req: <= 3)
Antibodies: 708 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1698.53 (req: >= 5)
Gene RIFs: 213 (req: > 3)
Antibodies: 708 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (142)
POTEI
Novelty: 0.41311202
p_int: 0.999911876
p_ni: 0.000088124
Score: 0.155
Data Source: BioPlex,STRINGDB
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.99978475
p_ni: 0.000207703
p_wrong: 0.000007547
Data Source: BioPlex
FAM126A
Novelty: 0.0250547
p_int: 0.999764407
p_ni: 0.000235585
p_wrong: 8e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
ACTB
Novelty: 0.00006048
p_int: 0.998831261
p_ni: 0.001168739
Score: 0.286
Data Source: BioPlex,STRINGDB
ACTA2
Novelty: 0.00199354
p_int: 0.99522956
p_ni: 0.00477044
Score: 0.447
Data Source: BioPlex,STRINGDB
NR2F2
Family: NR
Novelty: 0.00450561
p_int: 0.9873278
p_ni: 0.012672076
p_wrong: 1.24e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (4)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Reactome | Vitamin D (calciferol) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Vitamin D (calciferol) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 19 | 34 | 38 | 7.1 | 100 | ||||
vitamin D-binding protein measurement | 3 | 3 | 4 | 2068.1 | 99.4 | ||||
vitamin D deficiency | 1 | 1 | 1 | 95.6 | |||||
leukocyte count | 3 | 3 | 3 | 86.3 | |||||
neutrophil count | 4 | 3 | 4 | 85.8 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 38 | 7.1 | 100 | ||||
vitamin D-binding protein measurement | 4 | 2068.1 | 99.4 | ||||
vitamin D deficiency | 1 | 95.6 | |||||
leukocyte count | 3 | 86.3 | |||||
neutrophil count | 4 | 85.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | GC, vitamin D binding protein | VGNC:10382 | 461270 | |||||
Macaque | GC, vitamin D binding protein | 705708 | ||||||
Mouse | MGI:95669 | 14473 | ||||||
Rat | RGD:2667 | 24384 | ||||||
Dog | GC, vitamin D binding protein | VGNC:41136 | 475172 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | GC, vitamin D binding protein | |||||
Macaque | GC, vitamin D binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | GC, vitamin D binding protein | |||||
Publication Statistics
PubMed Score 1698.53
PubMed score by year
PubTator Score 867.53
PubTator score by year
Related Publications
Text Mined References (283)
GeneRif Annotations (213)
Items per page:
0 of 0
PMID | Year | Title |
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