Tchem GC Vitamin D-binding protein

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Vitamin D-binding Protein

DTO Classes

Protein / Transporter / Vitamin D-binding Protein

Protein Summary

Description

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P02774
• B4DPP2
• D6RAK8
• Q16309
• Q16310
• Q53F31
• Q6GTG1
• DBP

Gene Name

• GC

Ensembl ID

• ENST00000273951
• ENSP00000273951
• ENSG00000145321
• ENST00000504199
• ENSP00000421725

Symbol

• DBP
• VDB
• GRD3
• VDBG
• VDBP
• GcMAF
• DBP/GC
• Gc-MAF
• DBP-maf
• HEL-S-51

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.88
protein domain	0.85
cellular component	0.67
disease	0.65
disease perturbation	0.62

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1496.9   (req: < 5)

Gene RIFs: 213   (req: <= 3)

Antibodies: 708   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1496.9   (req: >= 5)

Gene RIFs: 213   (req: > 3)

Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

calcitriol

GCTchem

Kd : 7.62

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	14	13	19	8.3	100
vitamin D-binding protein measurement	EFO_0005675	1	2	0	2068.1	98.3
neutrophil count	EFO_0004833	3	3	3		89.8
myeloid white cell count	EFO_0007988	2	1	2		83.1
leukocyte count	EFO_0004308	2	2	2		70.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	19	8.3	100
vitamin D-binding protein measurement	EFO_0005675	0	2068.1	98.3
neutrophil count	EFO_0004833	3		89.8
myeloid white cell count	EFO_0007988	2		83.1
leukocyte count	EFO_0004308	2		70.2

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GC, vitamin D binding protein	VGNC:10382	461270
Macaque	GC, vitamin D binding protein		705708
Mouse	vitamin D binding protein	MGI:95669	14473
Rat	GC, vitamin D binding protein	RGD:2667	24384
Dog	GC, vitamin D binding protein	VGNC:41136	475172

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GC, vitamin D binding protein
Macaque	GC, vitamin D binding protein
Mouse	vitamin D binding protein
Rat	GC, vitamin D binding protein
Dog	GC, vitamin D binding protein

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02774-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (4)

PathwayCommons (1)

WikiPathways (1)

Metabolism (R-HSA-1430728)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of steroids	151 targets	R-HSA-8957322
Reactome	Vitamin D (calciferol) metabolism	11 targets	R-HSA-196791

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of steroids	151 targets	R-HSA-8957322
Vitamin D (calciferol) metabolism	11 targets	R-HSA-196791

Gene Ontology Terms (12)

Functions (4)

Components (6)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
calcidiol binding	Inferred from Direct Assay (IDA)	UniProtKB
actin binding	Inferred from Physical Interaction (IPI)	UniProtKB
vitamin D binding	Traceable Author Statement (TAS)	ProtInc
vitamin transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (142)

Explore Interacting Targets

1 – 10 of 142

• See Interactions on String-DB

POTEKP

Tdark

p_int: 0.999999994

p_wrong: 6e-9

Data Source: BioPlex

POTEF

Tbio

Novelty: 0.00191599

p_int: 0.999970473

p_ni: 0.000029527

Data Source: BioPlex

POTEI

Tdark

Novelty: 0.41311202

p_int: 0.999911876

p_ni: 0.000088124

Score: 0.155

Data Source: BioPlex,STRINGDB

DDX31

Tbio

Family: Enzyme

Novelty: 2.84646195

p_int: 0.99978475

p_ni: 0.000207703

p_wrong: 0.000007547

Data Source: BioPlex

FAM126A

Tbio

Novelty: 0.0250547

p_int: 0.999764407

p_ni: 0.000235585

p_wrong: 8e-9

Score: 0.691

Data Source: BioPlex,STRINGDB

ACTB

Tbio

Novelty: 0.00006048

p_int: 0.998831261

p_ni: 0.001168739

Score: 0.286

Data Source: BioPlex,STRINGDB

ACTA2

Tbio

Novelty: 0.00199354

p_int: 0.99522956

p_ni: 0.00477044

Score: 0.447

Data Source: BioPlex,STRINGDB

NR2F2

Tbio

Family: NR

Novelty: 0.00450561

p_int: 0.9873278

p_ni: 0.012672076

p_wrong: 1.24e-7

Score: 0.242

Data Source: BioPlex,STRINGDB

ACTBL2

Tbio

Novelty: 0.18080702

p_int: 0.971426195

p_ni: 0.028573805

Data Source: BioPlex

LRP2

Tbio

Novelty: 0.00143258

Score: 0.981

Data Source: STRINGDB

Publication Statistics

PubMed Score  1496.90

PubMed score by year

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PubTator Score  867.53

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Actin-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

granulocyte count
leukocyte count
lymphocyte count
monocyte count
myeloid white cell count
neutrophil count
platelet count
platelet crit
sum of basophil and neutrophil counts
sum of neutrophil and eosinophil counts

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
skeleton phenotype