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Tchem
GC
Vitamin D-binding protein

Protein Summary
Description
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273951
  • ENSP00000273951
  • ENSG00000145321
  • ENST00000504199
  • ENSP00000421725

Symbol
  • DBP
  • VDB
  • GRD3
  • VDBG
  • VDBP
  • GcMAF
  • DBP/GC
  • Gc-MAF
  • DBP-maf
  • HEL-S-51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.88
protein domain
0.85
cellular component
0.67
disease
0.65
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1496.9   (req: < 5)
Gene RIFs: 213   (req: <= 3)
Antibodies: 708   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1496.9   (req: >= 5)
Gene RIFs: 213   (req: > 3)
Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
calcitriol
chemical structure image
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
14
13
19
8.3
100
vitamin D-binding protein measurement
1
2
0
2068.1
98.3
neutrophil count
3
3
3
89.8
myeloid white cell count
2
1
2
83.1
leukocyte count
2
2
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
19
8.3
100
vitamin D-binding protein measurement
0
2068.1
98.3
neutrophil count
3
89.8
myeloid white cell count
2
83.1
leukocyte count
2
70.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GC, vitamin D binding protein
VGNC:10382
461270
Macaque
GC, vitamin D binding protein
705708
Mouse
MGI:95669
14473
Rat
RGD:2667
24384
Dog
GC, vitamin D binding protein
VGNC:41136
475172
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GC, vitamin D binding protein
Macaque
GC, vitamin D binding protein
Mouse
Rat
Dog
GC, vitamin D binding protein
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02774-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Vitamin D (calciferol) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroids
Vitamin D (calciferol) metabolism
Protein-Protein Interactions (142)
1 – 10 of 142
POTEKP
Tdark
p_int: 0.999999994
p_wrong: 6e-9
Data Source: BioPlex
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.999970473
p_ni: 0.000029527
Data Source: BioPlex
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.999911876
p_ni: 0.000088124
Score: 0.155
Data Source: BioPlex,STRINGDB
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.99978475
p_ni: 0.000207703
p_wrong: 0.000007547
Data Source: BioPlex
FAM126A
Tbio
Novelty: 0.0250547
p_int: 0.999764407
p_ni: 0.000235585
p_wrong: 8e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.998831261
p_ni: 0.001168739
Score: 0.286
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.99522956
p_ni: 0.00477044
Score: 0.447
Data Source: BioPlex,STRINGDB
NR2F2
Tbio
Family: NR
Novelty: 0.00450561
p_int: 0.9873278
p_ni: 0.012672076
p_wrong: 1.24e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.971426195
p_ni: 0.028573805
Data Source: BioPlex
LRP2
Tbio
Novelty: 0.00143258
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  1496.90

PubMed score by year
PubTator Score  867.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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