GC
Vitamin D-binding protein
Protein Summary
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
- ENST00000273951
- ENSP00000273951
- ENSG00000145321
- ENST00000504199
- ENSP00000421725
- DBP
- VDB
- GRD3
- VDBG
- VDBP
- GcMAF
- DBP/GC
- Gc-MAF
- DBP-maf
- HEL-S-51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.88 | ||
protein domain | 0.85 | ||
cellular component | 0.67 | ||
disease | 0.65 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1698.53 (req: < 5)
Gene RIFs: 303 (req: <= 3)
Antibodies: 708 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1698.53 (req: >= 5)
Gene RIFs: 303 (req: > 3)
Antibodies: 708 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1