Tbio AFP Alpha-fetoprotein

Protein Summary

Description

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02771
• B2RBU3

Gene Name

• AFP

Ensembl ID

• ENST00000395792
• ENSP00000379138
• ENSG00000081051

Symbol

• HPAFP
• AFPD
• FETA
• HPAFP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
chemical	0.93
gene perturbation	0.88
transcription factor perturbation	0.8
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Alpha-fetoprotein

DTO Classes

Protein / Transporter / Alpha-fetoprotein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25431.2   (req: < 5)

Gene RIFs: 344   (req: <= 3)

Antibodies: 3188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25431.2   (req: >= 5)

Gene RIFs: 344   (req: > 3)

Antibodies: 3188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0