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Tbio
AFP
Alpha-fetoprotein

Protein Summary
Description
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395792
  • ENSP00000379138
  • ENSG00000081051

Symbol
  • HPAFP
  • AFPD
  • FETA
  • HPAFP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
chemical
0.93
gene perturbation
0.88
transcription factor perturbation
0.8
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21875.24   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 3188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21875.24   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 3188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
1
1
81.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer biomarker measurement
1
81.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha fetoprotein
VGNC:6471
461258
Macaque
alpha fetoprotein
704786
Mouse
MGI:87951
11576
Rat
RGD:2065
24177
Dog
alpha fetoprotein
VGNC:37692
403551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha fetoprotein
Macaque
alpha fetoprotein
Mouse
Rat
Dog
alpha fetoprotein
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (333)
1 – 10 of 333
AHSG
Tbio
Novelty: 0.00112502
Score: 0.997
Data Source: STRINGDB
GPC3
Tbio
Novelty: 0.00151823
Score: 0.989
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.989
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.984
Data Source: STRINGDB
IGFBP1
Tchem
Novelty: 0.0006975
Score: 0.984
Data Source: STRINGDB
SERPINA1
Tbio
Novelty: 0.00014098
Score: 0.983
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.979
Data Source: STRINGDB
ITIH2
Tbio
Novelty: 0.04886358
Score: 0.972
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00404457
Score: 0.972
Data Source: STRINGDB
GOLM1
Tbio
Novelty: 0.00752112
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  21875.24

PubMed score by year
PubTator Score  11261.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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