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Tchem
ALB
Serum albumin

Protein Summary
Description
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
interacting protein
1
kinase perturbation
0.99
molecular function
0.9


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152051.18   (req: < 5)
Gene RIFs: 366   (req: <= 3)
Antibodies: 2613   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152051.18   (req: >= 5)
Gene RIFs: 366   (req: > 3)
Antibodies: 2613   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
albumin
VGNC:554
461260
Macaque
albumin
704892
Mouse
MGI:87991
11657
Rat
RGD:2085
24186
Dog
albumin
VGNC:37778
403550
Species
Name
OMA
EggNOG
Inparanoid
Chimp
albumin
Macaque
albumin
Mouse
Rat
Dog
albumin
Protein Structure (105 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02768-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 105
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Reactome
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Binding and Uptake of Ligands by Scavenger Receptors
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Disease
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (1355)
1 – 10 of 1355
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.979789373
p_ni: 0.020210627
Score: 0.187
Data Source: BioPlex,STRINGDB
CA8
Tbio
Family: Enzyme
Novelty: 0.0041859
p_int: 0.969325469
p_ni: 0.030674531
Score: 0.534
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.963017283
p_ni: 0.036982717
Data Source: BioPlex
OR2L13
Tdark
Family: oGPCR
Novelty: 0.3071575
p_int: 0.922158174
p_ni: 0.077841826
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.92122072
p_ni: 0.07877928
Score: 0.187
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.876699341
p_ni: 0.123300659
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.821490411
p_ni: 0.178509589
Score: 0.559
Data Source: BioPlex,STRINGDB
UPF3A
Tbio
Novelty: 0.01431609
p_int: 0.794604761
p_ni: 0.205395239
Score: 0.174
Data Source: BioPlex,STRINGDB
CCDC82
Tdark
Novelty: 0.48211191
p_int: 0.788257375
p_ni: 0.211742625
Score: 0.19
Data Source: BioPlex,STRINGDB
ADAMTS18
Tbio
Family: Enzyme
Novelty: 0.03614004
p_int: 0.767578004
p_ni: 0.232421996
Score: 0.224
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  152051.18

PubMed score by year
PubTator Score  17277.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer