Protein Summary
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculole ...more
- ENST00000237014
- ENSP00000237014
- ENSG00000118271
- ENST00000649620
- ENSP00000497927
- PALB
- CTS
- ATTR
- CTS1
- PALB
- TBPA
- HEL111
- HsT2651
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
drug | 1 | ||
gene perturbation | 1 | ||
disease perturbation | 0.83 | ||
chemical | 0.82 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8799.01 (req: < 5)
Gene RIFs: 349 (req: <= 3)
Antibodies: 1095 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8799.01 (req: >= 5)
Gene RIFs: 349 (req: > 3)
Antibodies: 1095 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 40
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 10
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
1 – 10 of 10
Active Ligands (40)
1 – 10 of 40
Protein-Protein Interactions (284)
1 – 10 of 284
MTMR6
Family: Enzyme
Novelty: 0.13067072
p_int: 0.99999231
p_ni: 0.00000769
Data Source: BioPlex
MTMR9
Novelty: 0.09702778
p_int: 0.999502406
p_ni: 0.000497594
Data Source: BioPlex
VWA1
Novelty: 0.00212445
p_int: 0.999048105
p_ni: 0.000883924
p_wrong: 0.000067971
Score: 0.201
Data Source: BioPlex,STRINGDB
NPC2
Novelty: 0.00342898
p_int: 0.997050137
p_ni: 0.002949734
p_wrong: 1.29e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.973196068
p_ni: 4.54e-7
p_wrong: 0.026803478
Score: 0.199
Data Source: BioPlex,STRINGDB
ATG7
Novelty: 0.00120728
p_int: 0.972243539
p_ni: 0.027756379
p_wrong: 8.2e-8
Data Source: BioPlex
SNX27
Novelty: 0.02419724
p_int: 0.968190156
p_ni: 5.36e-7
p_wrong: 0.031809309
Score: 0.253
Data Source: BioPlex,STRINGDB
INPP5A
Family: Enzyme
Novelty: 0.03249263
p_int: 0.962010511
p_ni: 0.037989484
p_wrong: 4e-9
Data Source: BioPlex
CES1
Family: Enzyme
Novelty: 0.00092608
p_int: 0.928087171
p_ni: 0.071912805
p_wrong: 2.4e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
FKBP7
Family: Enzyme
Novelty: 0.00572565
p_int: 0.923254383
p_ni: 0.076744107
p_wrong: 0.00000151
Score: 0.234
Data Source: BioPlex,STRINGDB
Pathways (23)
Reactome (21)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 21
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with visual transduction | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Disease | ||||
Diseases associated with visual transduction | ||||
Diseases of signal transduction | ||||
Extracellular matrix organization | ||||
Gene Ontology Terms (15)
Functions (4)
Components (5)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 5.5 | 14.2 | |||||
vitamin A measurement | 1 | 1 | 1 | 13.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 5.5 | 14.2 | |||||
vitamin A measurement | 1 | 13.2 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transthyretin | VGNC:5217 | 493188 | |||||
Macaque | transthyretin | 705943 | ||||||
Mouse | MGI:98865 | 22139 | ||||||
Rat | RGD:3916 | 24856 | ||||||
Dog | transthyretin | VGNC:47983 | 480167 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transthyretin | |||||
Macaque | transthyretin | |||||
Mouse | ||||||
Rat | ||||||
Dog | transthyretin | |||||
Publication Statistics
PubMed Score 8799.01
PubMed score by year
PubTator Score 2723.11
PubTator score by year