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Tclin
TTR
Transthyretin

Protein Summary
Description
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculole ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237014
  • ENSP00000237014
  • ENSG00000118271
  • ENST00000649620
  • ENSP00000497927

Symbol
  • PALB
  • CTS
  • ATTR
  • CTS1
  • PALB
  • TBPA
  • HEL111
  • HsT2651
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
gene perturbation
1
disease perturbation
0.83
chemical
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8455.64   (req: < 5)
Gene RIFs: 349   (req: <= 3)
Antibodies: 1095   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8455.64   (req: >= 5)
Gene RIFs: 349   (req: > 3)
Antibodies: 1095   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin A measurement
1
1
1
29.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin A measurement
1
29.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transthyretin
VGNC:5217
493188
Macaque
transthyretin
705943
Mouse
MGI:98865
22139
Rat
RGD:3916
24856
Dog
transthyretin
VGNC:47983
480167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transthyretin
Macaque
transthyretin
Mouse
Rat
Dog
transthyretin
Protein Structure (299 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02766-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 299
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Disease
Diseases associated with visual transduction
Diseases of signal transduction
Extracellular matrix organization
Protein-Protein Interactions (284)
1 – 10 of 284
MTMR6
Tbio
Family: Enzyme
Novelty: 0.13067072
p_int: 0.99999231
p_ni: 0.00000769
Data Source: BioPlex
MTMR9
Tbio
Novelty: 0.09702778
p_int: 0.999502406
p_ni: 0.000497594
Data Source: BioPlex
VWA1
Tbio
Novelty: 0.00212445
p_int: 0.999048105
p_ni: 0.000883924
p_wrong: 0.000067971
Score: 0.201
Data Source: BioPlex,STRINGDB
NPC2
Tbio
Novelty: 0.00342898
p_int: 0.997050137
p_ni: 0.002949734
p_wrong: 1.29e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.973196068
p_ni: 4.54e-7
p_wrong: 0.026803478
Score: 0.199
Data Source: BioPlex,STRINGDB
ATG7
Tbio
Novelty: 0.00120728
p_int: 0.972243539
p_ni: 0.027756379
p_wrong: 8.2e-8
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.968190156
p_ni: 5.36e-7
p_wrong: 0.031809309
Score: 0.253
Data Source: BioPlex,STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03249263
p_int: 0.962010511
p_ni: 0.037989484
p_wrong: 4e-9
Data Source: BioPlex
CES1
Tchem
Family: Enzyme
Novelty: 0.00092608
p_int: 0.928087171
p_ni: 0.071912805
p_wrong: 2.4e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
FKBP7
Tbio
Family: Enzyme
Novelty: 0.00572565
p_int: 0.923254383
p_ni: 0.076744107
p_wrong: 0.00000151
Score: 0.234
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8455.64

PubMed score by year
PubTator Score  2723.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer